grant
Dynamic Biological Hydrogels to Modulate Cardiac Remodeling Following Myocardial Infarction
Organization TUFTS UNIVERSITY MEDFORDLocation Boston, UNITED STATESPosted 1 Feb 2025Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAffectAgeAnimalsBinding SitesBiocompatible MaterialsBiologicalBiomaterialsBody TissuesCardiacCardiac DiseasesCardiac DisordersCardiac TransplantationCardiac infarctionCause of DeathCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCell-Extracellular MatrixCellsCellular ProliferationChemicalsClinical TrialsCollagenCombining SiteCommon Rat StrainsDataDevelopmentDiseaseDisorderDysfunctionECMEarly-Stage Clinical TrialsEchocardiogramEchocardiographyElasticityEnvironmentExtracellular MatrixFamily suidaeFetal HeartFiberFibroblastsFibrosisFormulationFunctional disorderGelGoldHeartHeart DiseasesHeart GraftingHeart TransplantationHeart failureHyaluronic AcidHydrogelsIn VitroInfarctionInjectableInjectionsInjuryLVADLeannessLeft VentriclesLeft ventricular structureMeasuresMechanicsModelingModificationModulusMonitorMyocardial InfarctMyocardial InfarctionMyocardiumNatural regenerationOrgan DonorParacrine CommunicationParacrine SignalingPathologicPersonsPhase 1 Clinical TrialsPhase I Clinical TrialsPhenotypePhysiologicPhysiologicalPhysiopathologyPigsPlayPre-Clinical ModelPreclinical ModelsProductionProgenitor CellsPropertyProteinsProteomicsRatRats MammalsRattusReactive SiteRegenerationRodentRodentiaRodents MammalsRoleSamplingSeriesSilkSuidaeSwineSystemTechniquesTestingTherapeuticThinnessTissuesTractionTransplantationTransthoracic EchocardiographyUnited StatesVascularizationVentricularWorkadulthoodagesbiologicbiological materialcardiac failurecardiac functioncardiac graftcardiac infarctcardiac musclecardiac regenerationcardiac repaircoronary attackcoronary infarctcoronary infarctioncrosslinkdevelopmentalexperimentexperimental researchexperimental studyexperimentsfetalfunction of the hearthealingheart attackheart disorderheart functionheart infarctheart infarctionheart muscleheart regenerationheart repairheart sonographyheart transplanthemodynamicsimplant materialimprovedin vivoinfarctinjuriesinterestjuvenile animalleft ventricular assist devicemechanicmechanicalmechanical propertiesnovelpathophysiologyphase I protocolporcinepre-clinicalpreclinicalpressurepreventpreventingprogenitorprogenitor cell differentiationprogenitor differentiationregenerateregeneration healingregeneration potentialregenerativeregenerative healingregenerative potentialrepairrepairedresponsesocial rolestandard carestandard treatmentstem and progenitor differentiationstem cell differentiationstem cellssuidtimelinetissue repairtooltransplantyoung animal
Description preview
Summary: Heart disease is the leading cause of death in the United States and there are currently over 5 million
people in the U.S. affected by heart failure (HF). One potential therapeutic that is currently undergoing Phase I
clinical trials is the injection of solubilized cardiac extracellular matrix (cECM) derived from adult porcine left…
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