grant
Dynamic and functional analysis of Enterococcus faecalis penicillin binding protein 4 pedestal domain
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AffectAffinityAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsBacteriaBindingBiochemical GeneticsBiophysicsCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Cephalosporin ResistanceCephalosporinsCessation of lifeClinical TreatmentCritical IllnessCritically IllCrystallizationDNA mutationDeathDevelopmentE faecalisE. faecalisEPR spectroscopyESR SpectroscopyElectron Paramagnetic ResonanceElectron Spin ResonanceElectron Spin Resonance SpectroscopyElectronsEnterococcusEnterococcus faecalisFellowshipFoundationsFunctional impairmentGI microbiomeGeneHomologGeneralized GrowthGenetic ChangeGenetic ScreeningGenetic TechnicsGenetic TechniquesGenetic defectGenetic mutationGrowthHomologHomologous GeneHomologous ProteinHomologueImpairmentIn VitroInfectionLeftLength of StayLightMedicalMicrobeMiscellaneous AntibioticMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMureinMutationNamesNegative Beta ParticleNegatronsNumber of Days in HospitalParamagnetic ResonancePatientsPenicillin Binding Protein 4Penicillin-Binding ProteinsPeptidoglycanPhenotypePhotoradiationPhysiciansPlayProliferatingProtein DynamicsProtein HomologProteinHomologProteinsRegulationResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistance to antibioticsResistant to Multiple DrugResistant to antibioticsResistant to multi-drugResistant to multidrugRoleS faecalisS. faecalisScientistStreptococcus Group DStreptococcus enterococcus groupStreptococcus faecalisSurfaceTestingTissue GrowthTrainingTraining ProgramsUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionVancomycin resistant enterococcusVancomycin-resistant enterococciVariantVariationWisconsinWorkanti-microbialantibiotic drug resistanceantibiotic resistantantimicrobialbacterial geneticsbiophysical foundationbiophysical principlesbiophysical sciencesblood infectionbloodstream infectioncephalosporin resistantclinical interventionclinical therapyconformationconformationalconformational stateconformationallyconformationscostcrosslinkdevelopmentaldigestive tract microbiomeelectron paramagnetic resonance spectroscopyenteric microbiomeexperienceflexibilityflexiblegastrointestinal microbiomegenome mutationgut microbiomegut-associated microbiomehospital dayshospital length of stayhospital stayin vivoinfection in the bloodinfection of the bloodinterdisciplinary approachintestinal biomeintestinal microbiomemedical collegemedical schoolsmortalitymulti-drug resistantmultidisciplinarymultidisciplinary approachmultidrug resistantmutantnamenamednamingnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyopportunistic pathogenprotein functionprotein protein interactionresistance to cephalosporinresistantresistant to cephalosporinschool of medicinesocial roletrial regimentrial treatmentvancomycin resistance enterococcivancomycin resistance in enterococci
Description preview
PROJECT SUMMARY/ABSTRACT:
Central line-associated bloodstream infections (CLABSI) are associated with increased patient
mortality, prolonged hospital stays, and increased cost burdens. Enterococci are intrinsically cephalosporin
resistant opportunistic pathogens that account for 16% of CLABSI cases. When a patient is treated with
cephalosporins,…
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