grant
Dual localization of angiopoietin like protein 4 in the extracellular milieu and nucleus regulates the hematogenous brain metastasis of triple negative breast cancer
Organization ARKANSAS STATE UNIVERSITYLocation STATE UNIVERSITY, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AIK geneARK1AURKAAURORA2AccelerationActive OxygenAik proteinAngiopoietinsAnoikisArkansasAthymic MiceAthymic Nude MouseAurora-Related Kinase 1Aurora/IPL1-Like KinaseAutocrine SystemsBTAKBindingBiomedical ResearchBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood-Brain BarrierBrainBrain MetastasisBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBrain VascularBreastBreast Cancer CellBreast Cancer PatientBreast Tumor PatientCardiac VentriclesCareer ChoiceCareer PathCell AttachmentCell CycleCell Cycle ArrestCell Cycle ControlCell Cycle ProteinsCell Cycle RegulationCell Division CycleCell Division Cycle ProteinsCell NucleusCell-Cycle Regulatory ProteinsCell-Matrix AdhesionsCell-Matrix JunctionCephalalgiaCephalgiaCephalodyniaCerebral EdemaCessation of lifeChromatinCirculationClinical TrialsCranial PainDataDeathDevelopmentDiagnosisDisease remissionEducationEducational aspectsEncephalonEnvironmentExtravasationFaceFutureGeneralized GrowthGenesGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGoalsGrowthHead PainHeadacheHeart VentricleHemato-Encephalic BarrierHematogenousHeterograftHeterologous TransplantationHumanImpairmentIntegrin BindingIntegrinsIntegrins Extracellular MatrixKnowledgeLeakageLeftLifeLife ExpectancyLinkLocationMalignant CellMedialMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BrainMetastatic TumorMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMitoticModelingModern ManMolecular InteractionMotorNeoplasm MetastasisNuclearNucleusNude MiceOperative ProceduresOperative Surgical ProceduresOutcomeOxygen RadicalsPalliative CarePalliative TherapyPalliative TreatmentPathway interactionsPatientsPolymerase Chain ReactionPro-OxidantsProcessProliferatingProteinsPublishingQOLQuality of lifeRadiationReactive Oxygen SpeciesRecombinant DNA TechnologyRemissionResearchResistanceSTK15STK6STK6 geneSTK6, Mouse, Homolog ofScienceSecondary NeoplasmSecondary TumorSeizuresSerine/Threonine Protein Kinase 15SiteSite-Directed MutagenesisSite-Specific MutagenesisSpeechSpillageSurfaceSurface ProteinsSurgicalSurgical InterventionsSurgical ProcedureTNBCTargeted DNA ModificationTargeted ModificationTestingTherapeuticTissue GrowthUniversitiesVascular EndotheliumVascular SystemXenograftXenograft ModelXenograft procedureXenotransplantationantagonismantagonistaurora kinasaurora kinase Aaurora-kinase Aautocrineblood-brain tumor barrierblood-tumor barrierbloodbrain barrierbloodbrain tumor barrierbrain micrometastasisbrain parenchymabreast tumor cellcancer cellcancer metastasiscareercareer aspirationcareer interestcareer pathwaycareer trackcdc Proteinscerebral vascularcerebro-vascularcerebrovascularchemotherapycomfort caredevelopmentaleffective interventionexperienceextracellularfacesfacialgenetically engineeredgenome editinggenomic editinggraduate studenthead achein vivo Modelindividuals with breast cancerinhibitorintegrin boundmembrane structuremouse modelmurine modelmutantontogenyoverexpressoverexpressionpalliative interventionparacrinepathwaypatient prognosispatients with breast cancerperson with breast cancerpre-clinicalpre-clinical developmentpreclinicalpreclinical developmentpreventpreventingprospectiveresistantshRNAshort hairpin RNAsmall hairpin RNAsurgerytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttriple-negative breast cancertriple-negative invasive breast carcinomatumor cell metastasistumors in the brainundergradundergraduateundergraduate studentvector controlxeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
Patients diagnosed with triple negative breast cancer (TNBC) brain metastasis face an uphill battle toward remission. Brain metastasis leads to cerebral edema, headaches, seizures, and motor and speech impairment, significantly impacting the patient’s quality of life during the treatment process. Nearly 80% of patients diagnosed with metastatic…
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