grant
Dose based aspirin pharmacokinetics and pharmacodynamics in pregnancy and association with pregnancy outcomes
Organization THOMAS JEFFERSON UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 13 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20261st trimester2-Hydroxybenzoic Acid21+ years old3rd trimesterAcetylsalicylic AcidAddressAdrenalineAdultAdult HumanArea Under CurveAspirinBMIBMI percentileBMI z-scoreBlackBlack raceBlood PlasmaBlood PlateletsBlood SerumBlood VesselsBody mass indexCells Placenta-TissueChronologic Fetal MaturityClinicalClinical EvaluationClinical ManagementClinical PharmacologyClinical TestingClinical TrialsComputer ModelsComputerized ModelsConsensusDataDependenceDevelopmentDiabetes MellitusDoseDrug KineticsDrugsEPH GestosisEarly Placental PhaseEnrollmentEpinephrineFetal AgeFirst Pregnancy TrimesterFirst TrimesterFutureGestationGestational AgeGovernmentGroups at riskGuidelinesHematologyHigh-Risk PregnancyHourImpairmentIndividualInsuranceInterventionKnowledgeLast TrimesterMarrow plateletMaternal HealthMaternal and Child HealthMeasuresMedicationMeta-AnalysisMethodsModelingMonitorMothersNormal PlacentomaObesityOutcomePK/PDParticipantPathologyPathway interactionsPatientsPeople at riskPerinatalPerinatologyPeripartumPersons at riskPharmaceutical PreparationsPharmacodynamicsPharmacokineticsPharmacologyPhasePlacentaPlacenta Embryonic TissuePlacentomePlasmaPlasma SerumPlateletsPopulationPopulations at RiskPre-EclampsiaPreeclampsiaPregnancyPregnancy OutcomePregnancy ToxemiasPremature BirthPrematurely deliveringPreterm BirthPreventionProteinuria-Edema-Hypertension GestosisQuetelet indexRandomization trialRandomizedRandomized, Controlled TrialsRecommendationRegimenRegression AnalysesRegression AnalysisRegression DiagnosticsResearchReticuloendothelial System, Serum, PlasmaRiskRisk ReductionRoleSalicylic AcidsSerumStatistical RegressionSubgroupTerm BirthTherapeutic EpinephrineThird Pregnancy TrimesterThird TrimesterThrombocytesThromboxanesTimeUrineValidationVisitadiposityadulthoodadverse consequenceadverse outcomeage associated effectsage effectage related effectsaging effectarmclinical careclinical efficacyclinical relevanceclinical testclinically relevantcomputational modelingcomputational modelscomputer based modelscomputerized modelingcorpulencecostdevelopmentaldiabetesdrug/agentefficacy clinical trialenrollfull-term birthfull-term newbornhigh riskimpact of ageimprovedinfluence of ageinnovateinnovationinnovativematernal conditionmaternal morbiditymortalitymultidisciplinaryneonatal healthneonatal morbiditynewborn healthnewborn morbiditynovelo-Hydroxybenzoic Acidortho-Hydroxybenzoic Acidoutcome predictionpathwaypatient populationperinatal outcomespharmacodynamic biomarkerpharmacodynamic markerpharmacokinetic modelpharmacokinetics and pharmacodynamicspre-eclampticpregnancy toxemia/hypertensionprematurepremature childbirthpremature deliveryprematuritypreterm deliverypreventpreventingrandomisationrandomizationrandomized control trialrandomized trialrandomly assignedreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresearch clinical testingresponserisk-reducingsalicylatesocial roleterm newbornvalidationsvascular
Description preview
PROJECT SUMMARY
Background: Aspirin is recommended in high risk pregnancies to reduce the risk of preeclampsia
and preterm birth, but up to 20% will still have these adverse outcomes. Recommendations for
aspirin dose range from 75mg-162mg daily. Gaps in knowledge regarding pregnancy specific
aspirin pharmacology and relationship between aspirin…
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