grant
Dopaminergic mechanisms for motivation and reinforcement learning
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Apr 2018Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026ACh ReceptorsAcetylcholine ReceptorsAddressAdenosineAffectAnesthesiaAnesthesia proceduresAnimalsAreaAxonBehaviorBehavioralBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChemicalsCholinergic ReceptorsCholinoceptive SitesCholinoceptorsCommon Rat StrainsCommunitiesComputer ModelsComputerized ModelsConnector NeuronCorpus StriatumCorpus striatum structureCuesD1 receptorD2 receptorDA NeuronDRD2 ReceptorDataData SetDopamineDopamine D1 ReceptorDopamine D2 ReceptorDopamine neuronDorsalElectrophysiologyElectrophysiology (science)EncephalonFeedbackFundingFutureGoalsHeterogeneityHydroxytyramineIndividualInfluentialsIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingLabelLateralLearningMeasurementMeasuresMedialMediatingMesencephalonMethodsMid-brainMidbrainMidbrain structureMonitorMotivationNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNicotinic Acetylcholine ReceptorsNicotinic ReceptorsNucleus AccumbensOpticsOutputPathologicPatternPopulationPropertyPsychological reinforcementRampRatRats MammalsRattusReceptor ProteinReinforcementResearchRewardsRoleShapesSignal TransductionSignal Transduction SystemsSignalingSliceStriate BodyStriatumStructureSubcellular ProcessSubstance abuse problemSynaptic plasticityTestingTimeTravelUncertaintyUpdateVentral Tegmental AreaWorkabuse of substancesabused drugabused drugsbehavior influencebehavioral influencebiological signal transductioncholinergiccomputational modelingcomputational modelscomputer based modelscomputerized modelingdiscountdopaminergic neurondoubtdrug abuseddrug of abusedrugs abuseddrugs of abuseelectrophysiologicalexpectationexperimentexperimental researchexperimental studyexperimentsinnovateinnovationinnovativemotivated behaviorneural circuitneural circuitryneurocircuitryneuronalnovelopticaloptogeneticspharmacologicprogramsreceptorresponsereward anticipationsensorsocial rolestriatalsubstance abusesynaptic circuitsynaptic circuitrytheoriesventral tegmentumwillingness
Description preview
Summary / Abstract
This research program seeks to describe and understand striatal dopamine (DA) signals, particularly in
the nucleus accumbens (NAc). NAc DA is a key regulator of both motivation and reward-related learning, and
drugs of abuse share the common property of enhancing NAc DA. Yet we lack a clear account of how DA
signals arise, how…
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