grant
Donor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgery
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Jan 2019Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025(TNF)-αActive OxygenAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryBasal Transcription FactorBasal transcription factor genesBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBody TissuesCX(3)C proteinCachectinCell BodyCell Communication and SignalingCell SignalingCell surfaceCell to Cell Communication and SignalingCell-Cell SignalingCellsChemokine (C-X3-C Motif) Ligand 1Clinical TrialsComplexDataDevelopmentDistantDysfunctionEffector CellEndotheliumEpitheliumFKN proteinFractalkineFunctional disorderFundingGFRP1Gene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGoalsGrowth Factor Response Protein 1Growth Factor-Inducible Nuclear Protein N10ImmuneImmunesImpairmentInfectionInflammatoryInjuryIntracellular Communication and SignalingIschemiaIschemia-Reperfusion InjuryKidneyKidney Urinary SystemLifeLungLung DiseasesLung GraftingLung Respiratory SystemLung TransplantationLung damageMGC9485Macrophage-Derived TNFMarrow NeutrophilMarrow monocyteMediatingMembraneMessenger RNAMitochondriaMolecularMonocyte-Derived TNFN10NAK-1NAK1NGFI-B proteinNGFIBNP10NR4A1NR4A1 geneNUR77Neutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteNr4a1 proteinNuclearNuclear Hormone Receptor TR3Nuclear Receptor Subfamily 4, Group A, Member 1NucleotidesOrganOrphan Nuclear Receptor HMROxygen RadicalsPathway interactionsPatientsPersonsPhasePhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPre-Clinical ModelPreclinical ModelsPrimary PreventionPro-OxidantsProceduresPublishingPulmonary DiseasesPulmonary DisorderPulmonary GraftPulmonary TransplantPulmonary TransplantationR-Series Research ProjectsR01 MechanismR01 ProgramRNA ExpressionReactive Oxygen SpeciesReperfusion DamageReperfusion InjuryReperfusion TherapyResearchResearch GrantsResearch Project GrantsResearch ProjectsResolutionRoleSeminalSeveritiesSignal InductionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine D1Steroid Receptor TR3Survival RateTLR proteinTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTR3TherapeuticTissuesToll-Like Receptor Family GeneToll-like receptorsTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransplant RecipientsTransplantationTransplantation SurgeryTumor Necrosis FactorTumor Necrosis Factor-alphaWorkacute kidney injurybiological signal transductionchemical releasedevelopmentaldisease of the lungdisorder of the lungexperienceexperimentexperimental researchexperimental studyexperimentsextracellular vesiclesfightinggraft dysfunctionimproved outcomeinjuriesinjury to organsinjury to tissueinnovateinnovationinnovativeinsightintercellular communicationlung allograftlung disorderlung injurylung transplantmRNAmembrane structuremigrationmitochondrialmonocytenerve growth factor-inducible Bneutrophilnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachorgan injuryorphan nuclear receptor NGFI-Borphan nuclear receptor NR4A1pathogenpathophysiologypathwaypreventpreventingpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrecruitrenalreperfusionresolutionssocial rolesuccesstherapeutic targettissue injurytranscription factortransplanttransplant patient
Description preview
Project Summary
Lung transplantation is a life-saving treatment for people with severe lung disease. However, complications like
primary graft dysfunction (PGD) can occur due to ischemia reperfusion injury (IRI), which limits the success of
the transplant. PGD often affects other organs, like the kidneys, and can reduce the 5-year survival rate of…
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