grant
Does lead (Pb) poisoning impair brain development by affecting how thyroid hormone gets into the brain?
Organization VIRGINIA POLYTECHNIC INST AND ST UNIVLocation BLACKSBURG, UNITED STATESPosted 15 Apr 2024Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20250-11 years oldAcquired brain injuryAddressAdverse effectsAffectAmphibiaAmphibiansAnimalsBiological MetamorphosisBrainBrain InjuriesBrain Nervous SystemCerebrospinal FluidChemicalsChildChild YouthChildren (0-21)Choroid PlexusCognitive deficitsCustomDevelopmentEncephalonFrogGasolineGene ExpressionGenesGoalsHealthHealth protectionHeavy MetalsHumanImaging ProceduresImaging TechnicsImaging TechniquesImpairmentL-ThyroxineLeadLead PoisoningLevothyroxineLiverMeasuresMediatingMental RetardationMissionModern ManMolecularNational Institutes of HealthNeuronal DifferentiationOutcomes ResearchPaintPb elementPb lead toxicityPb poisoningPb toxic effectPb toxicityPb2+ ToxicityPb2+ lead toxicityPb2+ poisoningPb2+ toxic effectPlasmidsPlatannaPlumbingPredispositionProcessProliferatingProtein BiosynthesisProteinsProteomicsProtocolProtocols documentationPublic HealthRanaRegulationResearchResolutionRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSourceSpinal ColumnSpineStructure of choroid plexusSusceptibilityT4 Thyroid HormoneTadpolesTechniquesTestingTherapeutic LevothyroxineThyroid Function TestsThyroid Gland Function TestsThyroid Gland HormoneThyroid HormonesThyroxineUnited StatesUnited States National Institutes of HealthVertebral columnWorkXenopusXenopus laevisXenopus sp.backbonebrain damagebrain sizebrain-injuredcerebral spinal fluidclawed frogcognitive defectscustomsdesigndesigningdevelopmentalexperimentexperimental researchexperimental studyexperimentsexpression vectorheavy metal Pbheavy metal leadhepatic body systemhepatic organ systemhormonal signalshormone signalsimaging in vivoimpaired brain developmentin uteroin vivo imaginginnovateinnovationinnovativeinsightkidsknock-downknockdownlead poisoningslead toxic effectlead toxicitymetamorphosisneurogenesisneuron toxicityneuronal toxicityneurotoxicitynew approachesnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionprotein expressionprotein functionprotein synthesisresolutionsspinal fluidthyroid disruptionthyroid functionthyroid hormone disruptionthyroxintoxic effect to leadtoxicity to leadyoungster
Description preview
Project Summary
Lead (Pb) poisoning is a persistent health issue in the United States due to legacy contamination from
Pb-based sources such as paint, plumbing, and gasoline. Children are most susceptible to Pb
poisoning, which causes persistent cognitive deficits and low IQ. The specific mechanisms by which Pb
poisoning impacts development are…
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