grant
Do auditory tests predict future Alzheimer’s disease pathophysiology
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAIDS VirusAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcquired brain injuryAffectAgeAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnatomic SitesAnatomic structuresAnatomyAudiogramAudiometric TestAudiometryAuditoryAβBiological MarkersBloodBlood Reticuloendothelial SystemBrainBrain InjuriesBrain Nervous SystemBrain imagingCentral Hearing LossCerebrospinal FluidCerebrumClinicalCochleaCochlear OrganCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataDementiaDepositDepositionDiffuseDisablingDisease Frequency SurveysDisease ProgressionDisturbance in cognitionDysfunctionEducationEducational aspectsEncephalonFunctional disorderFundingFutureGenerationsGroups at riskHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHearingHearing AidsHearing DisordersHearing LossHearing TestsHearing problemHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHypoacusesHypoacusisImageImpaired cognitionImpairmentIndividualInterventionLAV-HTLV-IIILongitudinal StudiesLymphadenopathy-Associated VirusMT-bound tauMeasuresNational Institutes of HealthNeuritic PlaquesNeurocognitiveNeurofibrillary TanglesNorth AmericaPETPET ScanPET imagingPETSCANPETTParticipantPathway interactionsPatientsPeople at riskPerformancePeripheralPersons at riskPhysiopathologyPopulations at RiskPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessProteinsRad.-PETResearchRisk FactorsSamplingSenile PlaquesSensory DeprivationSocio-economic statusSocioeconomic StatusSymptomsTest ResultTestingTimeUnited States National Institutes of HealthUniversitiesVirus-HIVWorka beta peptideabetaabnormal brain functionabnormally aggregated tau proteinadult youthagesalzheimer riskamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinassistive hearing deviceassistive listening deviceauditory diseaseauditory disorderauditory dysfunctionauditory pathwayauditory problemauditory processingauditory testsaβ plaquesbeta amyloid fibrilbio-markersbiologic markerbiomarkerbrain damagebrain dysfunctionbrain impairmentbrain visualizationbrain-injuredcerebralcerebral spinal fluidcognitive dysfunctioncognitive functioncognitive losscognitive performancecohortcored plaquedementia riskdesigndesigningdiffuse plaquedysfunctional braindysfunctional hearingfallsfilamentous tau inclusionhearing amplificationhearing assessmenthearing assistancehearing assistive devicehearing challengedhearing defecthearing deficienthearing deficithearing devicehearing difficultyhearing diseasehearing dysfunctionhearing impairmenthearing in noiseimagingimprovedinsoluble aggregatelong-term studylongitudinal outcome studiesmalleable riskmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmodifiable riskneurocognitive testneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologypaired helical filament of tauparticipant enrollmentpathophysiologypathwaypatient enrollmentperformance testspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreventpreventingprimary degenerative dementiaprotein aggregateprotein aggregationrate of changeresponse to therapyresponse to treatmentrisk factor for dementiarisk for dementiaself-aggregate tausenile dementia of the Alzheimer typesensory systemsocio-economic positionsocioeconomic positionsoluble amyloid precursor proteinsoundspeech in background noisespeech in noisespeech in speech recognitionspeech recognition in noisespinal fluidtangletautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau factortau fibrillizationtau filamenttau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau-tau interactiontherapeutic responsetherapy responsetreatment responsetreatment responsivenessyoung adultyoung adult ageyoung adulthoodτ Proteinsτ aggregation
Description preview
Hearing loss has been considered a risk factor for Alzheimer’s disease (AD), but the underlying mechanism
remains elusive. A “bottom-up” hypothesis has been suggested, where peripheral or cochlear damage at the
“bottom” of the auditory pathway accelerates AD pathophysiology by sensory deprivation. This hypothesis is
attractive because it suggests…
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