grant
DNA supercoiling and DNA topoisomerase in chromatin structure and function
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAcuteAssayBindingBioassayBiologicalBiological AssayBreast Cancer CellCell BodyCellsChromatinChromatin StructureDNA TopoisomerasesDiagnosisDiseaseDisorderDysfunctionEstrogen ReceptorsFunctional disorderGene Action RegulationGene ActivationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenomeGenomic SegmentGenomicsHumanHuman GenomeKineticsMeasuresMethodsModern ManMolecular InteractionPhysiopathologyPreventionProcessRNA ExpressionRegulationRelaxationResearchRoleShapesSingle cell seqSupercoiled DNASuperhelical DNASupertwisted DNATopoisomeraseTranscriptionTranscriptional ControlTranscriptional RegulationTwin Multiple BirthTwinsVisualizationWorkanalytical toolbiologicbreast tumor cellgenome scalegenome segmentgenome-widegenomewidegenomic regionglobal gene expressionglobal transcription profilehuman diseasehuman whole genomeinnovative technologiesinsightnovelpathophysiologyresponsesingle cell next generation sequencingsingle cell sequencingsocial rolethree dimensionaltooltranscriptome
Description preview
We have developed ATMP-seq, a novel assay that quantitatively measures both negative and positive DNA supercoiling across the genome. Using ATMP-seq, we characterized DNA supercoiling throughout the human genome, visualized twin-supercoiled domains around actively transcribed genes, and identified large-scale supercoiling domains (SDs). These SDs…
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