grant
DNA Methylation Dynamics of Mammalian Development
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 5 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025Aberrant DNA MethylationAbscissionAddressAssayAtlasesBioassayBiological AssayCell BodyCell LineageCellsChromatinChromosome MappingCommunitiesCoupledDNA MethylationDNA mappingDataData SetDepositDepositionDevelopmentDevelopmental BiologyDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsExcisionExpression SignatureExtirpationGatekeepingGene ExpressionGene Expression ProfileGene LocalizationGene MappingGene Mapping GeneticsGene TranscriptionGenesGenetic TranscriptionGenomeGenomicsHourLinkLinkage MappingMammalian CellMapsMethylationMiceMice MammalsModalityModificationMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMultiomic DataMurineMusNatureNon-Polyadenylated RNANucleosomesPatternPlayPopulationProcessProductionPropertyRNARNA ExpressionRNA Gene ProductsRegulationRemovalReporterResearchResearch ResourcesResolutionResourcesRibonucleic AcidRoleSpecific qualifier valueSpecifiedSurgical RemovalTamoxifenTechniquesTechnologyTestingTimeTotal Human and Non-Human Gene MappingTranscriptioncell typeconformationconformationalconformational stateconformationallyconformationscostdata portaldata sharing portaldemethylationdevelopmentaldevelopmental diseasedevelopmental disorderepigeneticallyepigenomeepigenomicsexperimentexperimental researchexperimental studyexperimentsgatekeepergene expression patterngene expression signaturegenetic mappinggenome scalegenome-widegenomewidehigh throughput technologyinsightintestinal epitheliummethylomemouse modelmultiomicsmultiple omic datamultiple omicsmurine modelnovelpanomicspermissivenesspluripotencypluripotent stateresectionresolutionssingle cell genomicssocial rolestemtooltranscriptional profiletranscriptional signaturetranscriptomics
Description preview
PROJECT SUMMARY
The progression from a pluripotent state into the myriad cell types that arise during mammalian development
involves a host of epigenetic properties that dictate gene expression patterns and enforce the commitment of a
cell to a specific lineage. The advent of single-cell genomics has enabled the study of cell lineage dynamics at…
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