grant
DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells
Organization UNIVERSITY OF TEXAS DALLASLocation RICHARDSON, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AdoptedAttentionBehaviorBenchmarkingBest Practice AnalysisCRISPRCRISPR libraryCRISPR-based libraryCRISPR/Cas systemCRISPR/Cas9 libraryCalibrationCell BodyCellsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats libraryComplexComputer AnalysisCoupledCustomDNA cassetteDataDevelopmentDevelopmental BiologyEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFeedbackGene ExpressionGene TranscriptionGenesGenetic TranscriptionHumanHuman Cell LineIndividualInstructionJointsKineticsLibrariesMathMath ModelsMathematical LogicMathematical ReasoningMathematicsMeasurementMedicineMessenger RNAMethodologyMethodsModalityModelingModern ManMolecular and Cellular BiologyNIGMSNational Institute of General Medical SciencesPhase TransitionPopulationPopulation StatisticsPropertyProteinsRNA ExpressionRegulationRelaxationResearchSortingStochastic ProcessesTechniquesTestingTimeTranscendTranscriptionbenchmarkbiological systemscomputational analysescomputational analysiscomputational frameworkcomputer analysescomputer based predictioncomputer frameworkcustomsdesigndesigningdevelopmentalenhancer cassetteepigenetic gene silencingepigenetic regulationepigenetic silencingepigeneticallyexperimentexperimental researchexperimental studyexperimentsexpression cassetteflexibilityflexiblegene cassettegene regulatory networkgenetic cassettegenome editinggenomic editinghybrid genein silicoinhibitorintegrated circuitintegrated circuitsintegration cassettemRNAmRNA Expressionmath analysismath theorymathematic modelmathematic theorymathematical analysismathematical modelmathematical modelingmathematical theorymathematics analysismathematics logicmathematics reasoningmathematics theorymodel-based simulationmodels and simulationpredictive modelingpromoter cassetteprotein expressionreporter cassetteresistance cassetteresponseselectable cassetteselection cassettesingle cell proteinssingle moleculestochastic methodstop cassettesynthetic biologytheoriestranscription cassettetranscriptional cassettetransgene cassette
Description preview
A major challenge at the interface of mathematics and molecular and cellular biology remains the
development of accurate and predictive models of epigenetic mechanisms. While eukaryotic transcription
is substantially influenced via epigenetic mechanisms, the majority of mathematical models pay little
attention to this crucial regulation…
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