grant
DLK1 regulates HSC quiescence through phase separation mediated inhibition of receptor signaling
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 15 May 2025Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAffectAffinityBindingBlood CellsBlood Precursor CellBody TissuesCD34CD34 geneCD34+ precursorCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation InhibitionCell Differentiation processCell SignalingCell divisionCell membraneCellsCo-cultureCocultivationCocultureCoculture TechniquesCord BloodCytoplasmic MembraneDNA Synthesis FactorDNA TherapyDevelopmentDiseaseDisorderEffectivenessEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEndothelial Cell Growth FactorEndothelial CellsEngraftmentExposure toExternal DomainExtracellular DomainFGFFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorFoundationsGene ExpressionGene TranscriptionGene Transfer ClinicalGeneHomologGenerationsGenetic InterventionGenetic TranscriptionGoalsHPCA1HSC agingHSC quiescenceHSC transplantationHematopoieticHematopoietic Progenitor CellsHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHematopoietic stem cellsHomologHomologous GeneHomologueHumulin RIn VitroInsulinIntracellular Communication and SignalingLeadLigandsMaintenanceMediatingMiceMice MammalsModelingMolecular InteractionMonitorMurineMusMyelogenousMyeloidNatureNotch Signaling PathwayNovolin ROrgan SizeOrganismPathway interactionsPb elementPeripheral Blood CellPhasePhenotypePhysical condensationPlasma MembranePopulationPreventionProcessProgenitor CellsProliferatingProteinsProteolysis and Signaling Pathway of NotchRNA ExpressionReceptor ActivationReceptor InhibitionReceptor ProteinReceptor SignalingRegular InsulinReportingReproducibilityResting progenitorSignal InductionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSupporting CellTestingTherapeuticTissuesTranscriptionTransplantationUmbilical Cord BloodUndifferentiatedadulthoodbiological signal transductionblood cell progenitorblood progenitorblood stem cellblood stem cell quiescenceblood stem cell transplantationblood-forming stem cellcellular differentiationcondensationdevelopmentaldormant stem cellengineered progenitor cellsengineered stem cellsexperimentexperimental researchexperimental studyexperimentsextracellularfetal cord bloodgene repair therapygene therapygene-based therapygenetic therapygenomic therapyheavy metal Pbheavy metal leadhematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitorhematopoietic progenitor cell transplantationhematopoietic stem cell aginghematopoietic stem cell quiescencehematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhypoimmunityimmune deficiencyimmunodeficiencyin vivoinactive stem cellknock-downknockdownlatent progenitorlatent stem cellliving systemmutantnew approachesnotchnotch proteinnotch receptorsnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionpathwayplasmalemmapreservationpreventpreventingprogenitor Cell growthprogenitor cell differentiationprogenitor cell expansionprogenitor cell functionprogenitor cell proliferationprogenitor differentiationprogenitor expansionprogenitor functionprogenitor growthprogenitor proliferationquiescent progenitorquiescent stem cellsreceptorresting stem cellscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem and progenitor cell expansionstem and progenitor cell functionstem and progenitor cell proliferationstem and progenitor differentiationstem and progenitor functionstem cell differentiationstem cell expansionstem cell functionstem cell growthstem cell proliferationstem cell quiescencestem cellssuccesstraffickingtransplant
Description preview
Project Summary: While much is known about factors that stimulate the proliferation and differentiation of stem
cells, less is known about the factors that prevent their differentiation and preserve their function. One factor
implicated in the maintenance of an undifferentiated stem cell state is the non-canoncial Notch ligand, Delta like…
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