grant
Dissociable roles of distinct orbitostriatal circuits in value-based decision-making
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 15 Mar 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY20264-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAddressAminalonAminaloneBehaviorBehavioralBrain regionCell BodyCellsCognitiveColorCommon Rat StrainsComplexComputer ModelsComputerized ModelsConnector NeuronCorpus StriatumCorpus striatum structureDecision MakingDevelopmentEnsureEnvironmentEquilibriumExhibitsFiberGABAGlutamatesGoalsHeterogeneityHybridsImpairmentIndividual DifferencesIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionKnowledgeL-GlutamateLateralLearningLinkLiteratureMajor Depressive DisorderMeasurementMeasuresMedialMediatingMediatorMental disordersMental health disordersModelingNerve CellsNerve UnitNeural CellNeurocyteNeuronsObsessive-Compulsive DisorderObsessive-Compulsive NeurosisOutputParvalbuminsPathway interactionsPatientsPerformancePhotometryProcessPsychiatric DiseasePsychiatric DisorderPsychological reinforcementQOLQuality of lifeRatRats MammalsRattusRegression AnalysesRegression AnalysisRegression DiagnosticsRegulationReinforcementResearchReversal LearningRewardsRoleSchizophreniaSchizophrenic DisordersSpecificityStatistical RegressionStrategic PlanningStriate BodyStriatumSubstance Use DisorderTask PerformancesTestingTherapeuticUpdatebalancebalance functionbehavior influencebehavioral influencecell typeclinical depressioncomputational frameworkcomputational modelingcomputational modelscomputational suitecomputer based modelscomputer frameworkcomputerized modelingdementia praecoxdevelopmentalenvironmental changeexperienceflexibilityflexiblefunctional disabilitygamma-Aminobutyric Acidglutamatergicinnervationinsightinterdisciplinary approachlearning activitylearning methodlearning strategieslearning strategyloss of functionmajor depressionmajor depression disordermental illnessmultidisciplinary approachnerve supplyneuralneural mechanismneurobiological mechanismneuromechanismneuronalneurophysiologicalneurophysiologynoveloptogeneticspathwaypsychiatric illnesspsychological disorderresponsereward processingschizophrenicsocial rolestemstriatalsubstance use and disordertherapeutically effectiveγ-Aminobutyric Acid
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7. Project Summary/Abstract
We make hundreds of decisions a day. Value-based decision-making requires the orchestration of multiple
processes that enable us to learn from prior experience and then use this information to guide our behavior.
Deficits in decision-making are common in psychiatric disorders that result from disruptions in how value is…
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