grant
Dissection of the TORC1 Signaling Network in Yeast
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Active Follow-upAddressAdenosine Cyclic Monophosphate-Dependent Protein KinasesAgingAmino AcidsBaker's YeastBrewer's YeastCancersCell BodyCell Communication and SignalingCell SignalingCellsCellular ExpansionCellular GrowthCellular Metabolic ProcessComplexCyclic AMP-Dependent Protein KinasesDevelopmentDiabetes MellitusDiseaseDisorderDissectionDrugsEpilepsyEpileptic SeizuresEpilepticsEukaryotaEukaryoteFutureGeneralized GrowthGrowthHumanIndividualIntermediary MetabolismIntracellular Communication and SignalingKinasesMalignant NeoplasmsMalignant TumorMapsMedicationMental DepressionMetabolic ControlMetabolic ProcessesMetabolismMicroscopyModelingModern ManNutrientObesityOutputPKAPathway interactionsPharmaceutical PreparationsPhosphotransferase GenePhosphotransferasesPlayProtein Kinase AProteinsPublic HealthRapamuneRapamycinRegulationReporterResearchRoleS cerevisiaeS. cerevisiaeSaccharomyces cerevisiaeSeizure DisorderSignal TransductionSignal Transduction SystemsSignalingSirolimusStarvationSystemTherapeutic FungicidesTissue GrowthTranscription RepressorTranscriptional RepressorTransmissionTransphosphorylasesWorkYeastsactive followupadiposityaminoacidanti-fungalanti-fungal agentsanti-fungal drugbiological signal transductioncAMP-Dependent Protein Kinasescell growthcell metabolismcellular metabaolismcorpulencedepressiondevelopmentaldiabetesdrug/agentepilepsiaepileptogenicexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupfungal pathogenfungi pathogengenetic repressorlive cell microscopymalignancymodel organismneoplasm/cancerontogenypathogenic funguspathwayphospho-proteomicsphosphoproteomicsresponsesocial roletranscriptomicstransmission process
Description preview
Summary
The Target of Rapamycin kinase Complex I (TORC1) is a central hub in the cell growth and metabolic control
network of eukaryotes. Studies carried out over the last twenty years have identified numerous components in
the TORC1 pathway, and uncovered the important role that TORC1 plays in diseases and disorders such as
cancer, epilepsy,…
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