grant
Dissecting the thermosensory biology of soil-transmitted parasitic nematodes
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAncylostomatidaeAntiparasitic AgentsAntiparasitic DrugsAntiparasiticsAutomobile DrivingAwardBehaviorBehavioralBehavioral AssayBilharziaBiological SymbiosisBiologyC elegansC. elegansC.elegansCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCaenorhabditis elegansCandidate Disease GeneCandidate GeneCas nuclease technologyCell Communication and SignalingCell SignalingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCuesCyclic GMPDNA Molecular BiologyDevelopmentEctopic ExpressionEnvironmentEvolutionExhibitsFoundationsGeneticGenetics-MutagenesisGenomeGenomicsGoalsGuanosine Cyclic MonophosphateHealthHelminthsHookwormsHumanHuman BiologyInfectionIntervention StrategiesIntracellular Communication and SignalingInvadedKnowledgeLarvaLifeLife CycleLife Cycle StagesLinkMammaliaMammalsMapsModelingModern ManMolecularMolecular BiologyMutagenesisMutagenesis Molecular BiologyNematodaNematodesNerve CellsNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurosciencesParasitesParasitic WormsParasitic nematodeParasiticidesParasitologyPathway interactionsPenetrationPersonsPhasePhylogenetic AnalysisPhylogeneticsPhysiologicPhysiologicalPhysiologyProcessReproductionResearchResolutionRoleSchistosomaSchistosomeSensoryShapesSignal TransductionSignal Transduction SystemsSignalingSkinSocioeconomically disadvantagedSoilStrongyloidesStrongyloides stercoralisSystemTRP channelTemperatureTherapeutic InterventionTransient receptor potential channelTransmissionWorkadulthoodbehavior responsebehavioral responsebiological signal transductioncGMPcommunity level disadvantagecomparativecomparative genomicsdesigndesigningdevelopmentaldisadvantaged communitydrivingexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgastrointestinalglobal healthinsightintervention therapyknockout genelife courseneighborhood barrierneighborhood disadvantageneighborhood-level barrierneighborhood-level disadvantageneuralneural adaptationneural circuitneural circuitryneural imagingneuro-imagingneuroadaptationneurocircuitryneuroimagingneurological imagingneuronalnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetparasitic roundwormparasitismpathwaypreferenceprogramsresolutionsresponseroundwormsocial rolesocio-economic disadvantagesocio-economically disadvantagedsocio-economically underprivilegedsocioeconomic disadvantagesocioeconomically underprivilegedsynaptic circuitsynaptic circuitrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltransmission processvirtual
Description preview
PROJECT SUMMARY
Soil-transmitted parasitic nematodes infect over a billion people around the world and can cause devastating
and sometimes fatal illness. Despite this massive health burden, the biology of parasitic nematodes remains
almost entirely unexplored. For example, we lack basic knowledge about the physiological specializations and
sensory…
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