grant
Dissecting the Role of TRPV1 in Triple-Negative Breast Cancer Innervation
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAP-1AP-1 Enhancer-Binding ProteinAP1AP1 proteinAccountingActivator Protein-1Adult femalesAdult womenAfferent NeuronsAssayAutomobile DrivingB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor GeneB-Cell Differentiation Factor-2B-Cell Stimulatory Factor 2 GeneB-Cell Stimulatory Factor-2BCDFBSF-2BSF-2 GeneBSF2BSF2 GeneBasal Transcription FactorBasal transcription factor genesBeta-2 Gene InterferonBinding SitesBioassayBiological AssayBody TissuesBreastBreast CancerBreast Cancer CellBreast Cancer cell lineBreast MetastasisBreast NeoplasmsBreast TissueBreast TumorsBreast tumor cell lineCancersCationsCause of DeathCell BodyCell Culture SystemCell secretionCell-Extracellular MatrixCellsCellular SecretionCessation of lifeClinicalCo-cultureCocultivationCocultureCoculture TechniquesCombining SiteComplexDeathDiseaseDisease-Free SurvivalDisorderDistantDorsal Root GangliaECMEnhancer-Binding Protein AP1EnvironmentEvent-Free SurvivalExhibitsExtracellular MatrixFatsFatty acid glycerol estersFellowshipFemaleFemales in adulthoodGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic TranscriptionGoalsGrowthHPGFHSF GeneHepatic Neoplasm SecondaryHepatic metastasisHepatocyte Stimulatory Factor GeneHepatocyte-Stimulating FactorHumanHybridoma Growth FactorHybridoma Growth Factor GeneHydrogelsIFN-beta 2IFNB2IFNB2 GeneIL-6IL-6 GeneIL6IL6 ProteinIL6 geneIn VitroInterleukin 6 (Interferon, Beta 2) GeneInterleukin-6Interleukin-6 GeneJUN Family GeneJUN Proto-oncogene FamilyJUN geneKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLiver secondariesLiver secondary cancerLuciferase ImmunologicLuciferasesMDA MB 231MDA-231MDA-MB231MGI-2Malignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMammary CancerMammary Gland ParenchymaMammary Gland TissueMammary NeoplasmsMediatingMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LiverMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LiverMetastatic Tumor to the LungMetastatic malignant neoplasm to liverMethodologyMiceMice MammalsModelingModern ManMonitorMurineMusMyeloid Differentiation-Inducing ProteinNatural regenerationNeoplasm MetastasisNerveNerve CellsNerve FibersNerve UnitNeural CellNeuritesNeurocyteNeuronsNuclearNull MouseOrganOrganism-Level ProcessOrganismal ProcessPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeripheral NervesPhysiciansPhysiologic ProcessesPhysiological ProcessesPlasmacytoma Growth FactorProcessRNA ExpressionReactive SiteRegenerationResearch ProposalsResearch TrainingRoleScientistSecondary NeoplasmSecondary TumorSecondary toSensorySensory NeuronsSiteSpinal GangliaSystemTNBCTRPV1TRPV1 geneTestingTissue GrowthTissuesTrainingTranscriptionTranscription Factor AP-1Transcription Factor Proto-OncogeneTranscription factor genesTumor CellUpregulationWomanWomen in adulthoodWorkafferent nerveantagonismantagonistbreast cancer metastasisbreast tumor cellc junc-jun Genecancer diagnosiscancer metastasiscancer microenvironmentcancer progressioncancer typecareerclinical trainingdensitydesigndesigningdorsal root gangliondrivingexperimentexperimental researchexperimental studyexperimentsexpression subtypeshydrogel scaffoldimprovedin vivoinnervationinnovateinnovationinnovativeinsightinterferon beta 2liver metastaseslung metastasismalignancymalignant breast tumormalignant liver neoplasm, specified as secondarymammarymammary tumormetastasis in the livermetastasis to the livermetastasize to the livermetastasize to the lungmetastatic cancer to livermetastatic livermetastatic liver neoplasmmigrationmolecular sub-typesmolecular subsetsmolecular subtypesmortalitymouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnerve supplyneuronalnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetontogenypatient oriented outcomespharmacologicphysiologic modelpre-docpre-doctoralpulmonary metastasisrecruitregeneratesecondary liver malignancysecondary malignant liver neoplasmsensory nervesocial rolethree dimensionalthree-dimensional modelingtranscription factortranscriptomicstransient receptor potential cation channel V1triple-negative breast cancertriple-negative invasive breast carcinomatumortumor cell metastasistumor growthtumor microenvironmenttumor progression♀
Description preview
PROJECT SUMMARY:
Breast cancer is the most common form of malignancy in women, accounting for almost one in three new female
cancer diagnoses each year. The primary cause of breast cancer-related deaths is metastatic disease, where
tumor cells disseminate to secondary sites in the body. Human breast tumors exhibit increased sensory nerve
fiber…
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