grant
Dissecting the role of mirtrons in human cancers
Organization TEXAS TECH UNIVERSITYLocation LUBBOCK, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AddressAdoptedAlkaline PhosphataseAntigen PresentationBindingBinding SitesBiogenesisBiologicalBreast CancerBreast Cancer CellBreast Cancer cell lineBreast tumor cell lineBypassCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer TreatmentCancersCas nuclease technologyCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCellular Immune FunctionChemistryClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCombining SiteDKFZp547I0610DKFZp564I0682DNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDevelopmentDigestionDiseaseDisease ProgressionDisorderEctopic ExpressionEndocytosisEndosomesEnsureEnzyme GeneEnzymesEventExhibitsExoribonucleasesExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGenerationsGuanineGuanine NucleotidesGuanosineGuanosine PhosphatesHumanImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunityImmunoglobulin Enhancer-Binding ProteinImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunomodulationInterruptionIntracellular Communication and SignalingKIAA0012Knock-outKnockoutKnowledgeLeadLibrariesLigand BindingLigandsLinkLiteratureLower OrganismMacrophageMalignant Breast NeoplasmMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMammaliaMammalsMediatingMethodologyMicroRNAsModern ManModificationMolecular InteractionMonitorMφNF-kBNF-kappa BNF-kappaBNFKBNon-Polyadenylated RNANormal CellNuclear Factor kappa BNuclear Transcription Factor NF-kBNucleotidesOrigin of LifePb elementPoly APoly(rA)PolymeraseProcessProductionPropertyProteinsRNARNA Gene ProductsRNA NucleasesRNA PolymerasesRNA SplicingRNA VirusesRNaseReactionReactive SiteReceptosomesRegulationReporterResearchResistanceRibonuclease Family ProteinRibonucleasesRibonucleic AcidRoleSignal TransductionSignal Transduction SystemsSignalingSiteSmall RNASortingSpectroscopySpectrum AnalysesSpectrum AnalysisSplicingStrains Cell LinesStructureTLR1TLR1 geneTLR1 proteinTLR1 receptorTLR7TLR7 geneTailTechnologyTestingTherapeuticTherapeutic InterventionToll-Like Receptor 1Toll-Like Receptor 7Toll/Interleukin-1 Receptor-LikeTranscription Factor NF-kBTumor PromotionWorkalkaline phosphomonoesteraseanti-cancer therapybiologicbiological signal transductionbreast tumor cellcancer cellcancer progressioncancer sub-typescancer subtypescancer therapycancer-directed therapycultured cell linecytokinedevelopmentalexosomeexperimentexperimental researchexperimental studyexperimentsfightingflow cytophotometrygene regulatory networkglycerophosphataseheavy metal Pbheavy metal leadhost responsehuman diseaseimmune functionimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinhibitorintervention therapykappa B Enhancer Binding Proteinknock-downknockdownmalignancymalignant breast tumormiRNAneoplasm progressionneoplasm/cancerneoplastic progressionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynuclear factor kappa betanucleasepolyadenylatepreventpreventingresistantrsc786selective expressionselectively expressedsocial roletherapeutically effectivetumortumor progressionvector
Description preview
Project Summary/Abstract
Mirtrons are a new class of small RNAs. Previous findings show mirtrons are generated by splicing and
are less stable than canonical miRNAs. Thus, the expression of mirtrons is often negligible. Additionally, most
mirtrons exhibit distinct evolutionary properties relative to solo and mammals have way more mirtrons than…
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