grant
Dissecting the role and mechanism of EML4-ALK condensates in oncogenic signaling and tumor growth
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 11 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025ALK geneALK proteinASH ProteinAbundant SRC HomologyAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAnaplastic Lymphoma Kinase Ki-1Applications GrantsArchitectureBiologicalBiologyCD246 AntigenCancer CauseCancer ControlCancer Control ScienceCancer EtiologyCancer PatientCancersCell BodyCell Communication and SignalingCell Membrane LipidsCell SignalingCellsChimera ProteinChimeric ProteinsClinicalComplementComplement ProteinsComplexCytoplasmic GranulesCytoplasmic ProteinDNA RearrangementDataDevelopmentDrug resistanceEGF ReceptorEGFRERBB ProteinEngineering / ArchitectureEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsExtracellular Signal-Regulated Kinase GeneFoundationsFusion Oncogene ProteinsFusion ProteinFutureGRB-2GRB2GRB2 ProteinGRB2 adaptor proteinGRB2 geneGene RearrangementGeneralized GrowthGeneticGenetics-MutagenesisGoalsGrant ProposalsGrowthHER1HLA-DR Associated Protein IIHistologicHistologicallyIGAADInhibitor of GZMA-Activated DNaseIntracellular Communication and SignalingKinasesLung AdenocarcinomaMAP Kinase GeneMAPKMalignant CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMembraneMembrane LipidsMethodologyMitogen-Activated Protein Kinase GeneMolecularMutagenesisMutagenesis Molecular BiologyNSCLCNSCLC - Non-Small Cell Lung CancerNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaOncogene ProductsOncogene ProteinsOncogenicOncoproteinsOutcomeOutputPTK ReceptorsPathogenicityPathway interactionsPatientsPhasePhenotypePhosphatase 2A Inhibitor I2PP2APhosphotransferase GenePhosphotransferasesPhysical condensationProteinsProteomicsPulmonary CancerPulmonary malignant NeoplasmReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneRecurrenceRecurrentRoleSET Translocation Inhibitor-2 of Protein Phosphatase-2ASet proteinSignal TransductionSignal Transduction SystemsSignalingTGF-alpha ReceptorTemplate Activating Factor I BetaTestingTherapeuticTissue GrowthTransforming Growth Factor alpha ReceptorTransmembrane Receptor Protein Tyrosine KinaseTransphosphorylasesTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsUrogastrone ReceptorVariantVariationWorkabundant Src homology proteinadapter proteinanaplastic lymphoma kinaseanaplastic lymphoma kinase genebiologicbiological signal transductionc-erbB-1c-erbB-1 Proteincancer cellclinical relevanceclinically relevantcomplementationcondensationdesigndesigningdevelopmentaldrug resistanterbB-1erbB-1 Proto-Oncogene ProteinerbBlfusion oncoproteingenetic approachgenetic strategygranulegrowth factor receptor-bound protein 2improvedinnovateinnovationinnovativeinsightkinase inhibitorlung cancermalignancymembrane structuremortalitymultidisciplinarymutantneoplasm/cancerontogenypathwayprecision medicineprecision-based medicineprotein expressionproto-oncogene protein c-erbB-1recruitresistance to Drugresistant to Drugresponsesocial roletooltreatment strategytumor growth
Description preview
PROJECT ABSTRACT. Lung cancer is the leading cause of cancer mortality worldwide, with non-small cell lung
cancer (NSCLC) the predominant histologic subtype of lung cancer and lung adenocarcinoma the major subset
of NSCLC. ALK gene rearrangements (e.g., EML4-ALK fusions) are validated targets in NSCLC and current ALK
kinase inhibitors yield…
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