grant
Dissecting the Myeloid-Th17 axis in the pathogenesis of Colitis-associated Colorectal Cancer
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 3 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025ARG2ARG2 geneAddressAttenuatedAutomobile DrivingAzoxymethaneB7-H1Blood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBurkitt HerpesvirusBurkitt Lymphoma VirusCD11bCD274CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCLMF2CR3ACTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCancer CauseCancer EtiologyCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell Growth and MaintenanceCell MaintenanceCell SignalingCellsCessation of lifeCheckpoint inhibitorChronicColitis associated colon cancerColitis associated colorectal cancerColitis induced colorectal cancerColonColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic TumorColonic inflammationColorectal CancerComplexCytotoxic Lymphocyte Maturation Factor 2Cytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDSS colitisDSS modelDSS mouse modelDSS-induced acute colitisDSS-induced colitisDeathDevelopmentDiazene, dimethyl-, 1-oxideDigestive DiseasesDigestive System DiseasesDigestive System DisordersDimerizationDiseaseDisease ProgressionDisorderEB virusEBVEdodekin AlfaEpstein Barr VirusEventFamilyFeedbackFoundationsGI tract disorderGamma-delta T cellsGene ExpressionGeneralized GrowthGenesGrowthHHV-4HHV4HeterogeneityHuman Herpesvirus 4IL-12IL-12BIL-17IL-17 GeneIL-17AIL-17A GeneIL12IL12, subunit p40IL12BIL12B geneIL17IL17 ProteinIL17 geneIL17AIL17A GeneITGAMITGAM geneImmuneImmune checkpoint inhibitorImmunesIncidenceIndividualInfectious Mononucleosis VirusInfiltrationInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin 23, p40 SubunitInterleukin-12Interleukin-12BInterleukin-17InterleukinsIntervention StrategiesIntracellular Communication and SignalingInvadedKineticsLinkMAC1AMO1AMacrophageMaintenanceMarrow NeutrophilMarrow monocyteMediatingMediatorMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMolecularMurineMusMyelogenousMyeloidMyeloid CellsMφNKSFNKSF2Natural Killer Cell Stimulatory FactorNatural Killer Cell Stimulatory Factor, 40-KD SubunitNeoplasm MetastasisNeutrophilic GranulocyteNeutrophilic LeukocyteOncogenesisPD-L1PDL-1PathogenesisPathogenicityPathway interactionsPatientsPhasePlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationProcessProductionPrognosisProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1Protein DimerizationResistanceRisk FactorsRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSourceT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTherapeuticTissue GrowthTumor PromotionTumor-associated macrophagesUnited StatesVEGFVEGFsVascular Endothelial Growth FactorsWorkangiogenesisarginase 2arginase IIattenuateattenuatesbiological signal transductionbowel inflammationcancer metastasiscancer microenvironmentcancer progressioncellular differentiationchronic inflammatory diseasecolitis induced colon cancercolitis-induced dysbiosiscolon carcinogenesiscolon neoplasiacolorectal cancer progressioncolorectal carcinogenesiscytokinedesigndesigningdevelopmentaldextran sulfate sodium colitisdextran sulfate sodium induced colitisdextran sulfate sodium modeldextran sulfate sodium mouse modeldigestive disorderdigestive tract diseasedrivinggastrointestinal tract diseasegastrointestinal tract disordergut inflammationimmune check point inhibitorimprovedinflamed bowelinflamed coloninflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinsightintestinal autoinflammationintestinal inflammationmonocytemortalityneoplasm progressionneoplastic progressionneutrophilnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathwaypreventpreventingprogrammed cell death ligand 1programmed cell death protein ligand 1protein death-ligand 1rational designrecruitresistantresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesynergismthymus derived lymphocytetreatment strategytumortumor cell metastasistumor microenvironmenttumor progressiontumorigenesistumorigenicγδ T cellsγδT cells
Description preview
Colorectal cancer (CRC) is the second-leading cause of cancer-related mortality in the United States. Chronic
intestinal inflammation is a major risk factor for the development and progression of sporadic and colitis-
associated colorectal cancer (CAC). While the pathogenic effects of tumor-promoting inflammation are widely
recognized, the…
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