grant
Dissecting the effect of diet on gut microbiome metabolism
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 16 Dec 2024Deadline 15 Dec 2028
NIHUS FederalResearch GrantFY202616S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqAffectAmino AcidsAutomobile DrivingAutoregulationBacteriaBiological Response ModifiersBiomodulatorsBlood SerumCarbolCarbolic AcidCelluloseColonDataDietDiet ModificationDietary ComponentDietary FiberDietary FormulationsDietary ModificationsDietary ProteinsDietary intakeDigestionDiseaseDisorderEquilibriumFecesFermentationFiberFood PreferencesFood ProcessingFoundationsGI microbiomeGI microbiotaGastrointestinal microbiotaGoalsGut EpitheliumHippuric acidHomeostasisHourHydroxybenzeneImmune MediatorsImmune Mediators/ModulatorsImmune ToleranceImmunologic ToleranceIndolesInflammatory Bowel DiseasesInflammatory Bowel DisorderInfusionInfusion proceduresIntermediary MetabolismIntestinalIntestinesInulinIsotopesL-TryptophanLC/MSLabelLevotryptophanLinkMeasuresMechanicsMediatingMetabolic ProcessesMetabolismMethodsMiceMice MammalsMucinsMucous body substanceMucusMucus GlycoproteinMurineMusObesityPatientsPectinsPhenolsPhenylalaninePhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPolyanhydroglucuronic AcidProcessProductionProtein DenaturationProtein SecretionProteinsRouteSchemeSerumSmall IntestinesSourceTechniquesTestingThickThicknessTryptophanWorkabsorptionadiposityahr ligandalpha-Celluloseaminoacidaryl hydrocarbon receptor ligandbalancebalance functionbenzamidoacetic acidbenzoylglycinebowelcinnamic acidcookingcorpulencediet alterationdiet choicediet controldiet preferencedietarydietary alterationdietary choicedietary controldietary preferencesdietsdigestive tract microbiomedrivingenteric microbial communityenteric microbiomeenteric microbiotafecal samplefeedingfood choicegastrointestinal epitheliumgastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehistologic stainshistological stainsimmune system toleranceimmune unresponsivenessimmunological paralysisinflammatory disease of the intestineinflammatory disorder of the intestineinfusionsinsoluble aggregateintestinal autoinflammationintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraliquid chromatography mass spectrometrymechanicmechanicalmethoxy pectinmethoxylpectinmethoxypectinmicrobialmicrobial compositionmicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremouse modelmucousmurine modelobesigenicobesogenicpectinic acidprotein aggregateprotein aggregationsmall bowelstoolstool samplestool specimentool
Description preview
Project Summary
Gut microbiome products such as indole and phenol metabolites have major impacts on host physiology.
Decreased production of these important metabolites is linked with many diseases, and increasing circulating
concentrations of indole or phenol metabolites ameliorates inflammatory bowel disease or obesity in mouse
models,…
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