grant
Dissecting Orchestrated Immune Responses to Glioblastoma within the Native Tissue Microenvironment to Improve Treatment Outcomes
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 15 May 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025After CareAfter-TreatmentAftercareAnatomic SitesAnatomic structuresAnatomyAnimalsArchitectureAreaBody TissuesBrain CancerCNS Nervous SystemCancersCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCentral Nervous SystemChemotherapy and RadiationChemotherapy and/or radiationClinicClinicalComputing MethodologiesData SetDevelopmentDexamethasoneEGF ReceptorEGFREGFR inhibitionERBB ProteinEngineering / ArchitectureEnvironmentEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEvolutionGEM modelGEMM modelGenetically Engineered MouseGenomicsGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHER1HeterogeneityHumanHuman CharacteristicsHuman NatureImmuneImmune responseImmunesIn SituInfiltrationIntracellular Communication and SignalingIonizing Electromagnetic RadiationIonizing radiationKnowledgeLinkLocationMalignantMalignant - descriptorMalignant CellMalignant Glial NeoplasmMalignant Glial TumorMalignant GliomaMalignant NeoplasmsMalignant Neuroglial NeoplasmMalignant Neuroglial TumorMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMiceMice MammalsModalityModern ManMolecularMurineMusMyeloid CellsNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuroglial NeoplasmNeuroglial TumorNeuronsPTK ReceptorsPatientsPopulationPopulation DynamicsProteomicsRadiation-Ionizing TotalReactionReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneResearchResistanceResolutionRoleSamplingSignal TransductionSignal Transduction SystemsSignalingTGF-alpha ReceptorTechnologyTemodalTemodarTherapeuticTissuesTransforming Growth Factor alpha ReceptorTransmembrane Receptor Protein Tyrosine KinaseTreatment outcomeTumor CellTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsUrogastrone Receptorbiological signal transductionc-erbB-1c-erbB-1 Proteincancer cellcancer immunologycancer microenvironmentchemo/radiation therapychemotherapychemotherapy and radiotherapyclinical relevanceclinical significanceclinically relevantclinically significantcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddesigndesigningdevelopmentaldisease controldisorder controleffective therapyeffective treatmenterbB-1erbB-1 Proto-Oncogene ProteinerbBlfractionated radiationgenetically engineered mouse modelgenetically engineered murine modelglial-derived tumorglioblastoma multiformeglobal gene expressionglobal transcription profilehost responsehuman dataimmune microenvironmentimmune system responseimmunological statusimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedionizing outputirradiationkinase inhibitormalignancymembermethazolastonemouse modelmurine modelneoplasm immunologyneoplasm/cancerneoplasticneoplastic cellneuroglia neoplasmneuroglia tumorneuronalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoverexpressoverexpressionpost treatmentpre-clinicalpreclinicalproto-oncogene protein c-erbB-1radiation or chemotherapyresistantresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicsspongioblastoma multiformestandard of caretemozolomidetranscriptometumortumor immune microenvironmenttumor immunologytumor microenvironmenttumor-immune system interactionstumorigenic
Description preview
Project Summary
The interpatient and intratumoral cellular heterogeneity of glioblastoma (GBM) is a major driver of up front therapy
resistance and responsible for GBM’s brief median survival (~15 months). We and others have discovered that
the transcriptomes of neoplastic GBM cells is heavily influenced by their anatomical localization. This led…
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