grant
Dissecting heterogeneity in hematopoietic stem and progenitor cell ontogeny
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AbscissionAssayBioassayBiological AssayBloodBlood DiseasesBlood Precursor CellBlood Reticuloendothelial SystemBody TissuesBrachydanio rerioCell BodyCell OntogenyCellsCessation of lifeClassificationClinicalComplexCoupledDanio rerioDataDeathDefectDevelopmentDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEnvironmentExcisionExpression SignatureExtirpationGene Expression ProfileGene TranscriptionGeneralized GrowthGenerationsGeneticGenetic ScreeningGenetic TranscriptionGrowthHSC productionHematologic Body SystemHematologic DiseasesHematologic Organ SystemHematological DiseaseHematological DisorderHematopoiesisHematopoieticHematopoietic Body SystemHematopoietic Cell ProductionHematopoietic Cell TumorHematopoietic Cellular Control MechanismsHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic Progenitor CellsHematopoietic SystemHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsHematopoietic stem cellsHeterogeneityHortega cellIQ DeficitImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIn Situ HybridizationKnowledgeLineage TracingLymphoidLymphoid CellMacrophageMalignant Hematopoietic NeoplasmMeasuresMicrogliaModelingMyelogenousMyeloidMyeloid CellsMφNerve DegenerationNeurocognitive DeficitNeuron DegenerationOrganismOutputPatientsPluripotent Stem CellsPopulationPositionPositioning AttributeProceduresProgenitor CellsPropertyPublic HealthRNA ExpressionRecommendationRegulationRemovalResearchRoleSourceStem Cell likeSurgical RemovalSystemSystematicsTestingTextTimeTissue GrowthTissuesTranscriptionTransplantationVisualizationWorkZebra DanioZebra FishZebrafishatheroprotectionatheroprotectiveblood cancerblood cell formationblood cell progenitorblood disorderblood progenitorblood stem cellblood-forming stem cellcancer of bloodcancer of the bloodcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingdevelopmentalgene expression patterngene expression signaturegitter cellhematopoietic progenitorhematopoietic stem cell productionhematopoietic stem progenitor cellhematopoietic transplantationhemopoietichemopoietic progenitorhemopoietic stem cellhuman derived pluripotent stem cellhuman pluripotent stem cellhypoimmunityimmune deficiencyimmunodeficiencyin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivointelligence quotient deficitintra-vital imagingintravital imaginglife spanlifespanliving systemmesogliamicroglial cellmicrogliocytemultipotencymultipotentneural degenerationneurocognitive declineneurocognitive impairmentneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationontogenyperivascular glial cellpluripotent progenitorprogenitorprogenitor capacityprogenitor cell functionprogenitor cell likeprogenitor functionprogenitor-likeprogramsresectionscRNA sequencingscRNA-seqself-renewself-renewalsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial and temporalspatial temporalspatiotemporalstemstem and progenitor cell functionstem and progenitor functionstem cell characteristicsstem cell functionstem cellsstem-likestemnesstooltranscriptional profiletranscriptional signaturetransplant
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The hematopoietic and immune landscape is complex. The assortment is generated and sustained by the function of hematopoietic stem cells (HSCs) and progenitor cells that arise independently during embryonic…
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