grant
DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCE
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 15 Aug 2013Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Adeno-Associated VirusesAffective DisordersAlcohol Chemical ClassAlcoholsAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnxietyAssociated VirusesBehaviorBehavioralBehavioral ModelBiologicalBrainBrain Nervous SystemCRE RecombinaseCRISPRCRISPR/Cas systemCaM KIICaM PK IICaM kinase IICaMKIICalciumCartoonsCell BodyCellsCessation of lifeChemosensitizationChemosensitization/PotentiationClaustral structureClaustrumClustered Regularly Interspaced Short Palindromic RepeatsCocaineCornu AmmonisCorpus StriatumCorpus striatum structureDeathDependoparvovirusDependovirusDiacetylmorphineDiamorphineDorsalDrug RegulationsDrug abuseDrugsDynorphinsElectrophysiologyElectrophysiology (science)EncephalonEnterobacteria phage P1 Cre recombinaseGeneticGlutamatesHeroinHippocampusImageIn vivo two-photon calcium imagingInstructionL-GlutamateLearningLigandsLinkMeasuresMediatingMedicationMemoryMethodsMiceMice MammalsModelingMood DisordersMotivationMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropharmacologyNeurophysiology / ElectrophysiologyNicotineNicotine DependenceNucleus AccumbensOpiate AddictionOpiate DependenceOpiate PeptidesOpiate ReceptorsOpiate agonistOpiate receptor agonistOpiatesOpioidOpioid PeptideOpioid ReceptorOpioid agonistOpioid receptor agonistOutcomePharmaceutical PreparationsPharmacologyPhotometryPlayPotentiationProcessReceptor ActivationReceptor ProteinRegulationRelapseReportingRewardsRiskRoleSatellite VirusesSelf AdministeredSelf AdministrationSiteSliceStressStriate BodyStriatumSynapsesSynapticSynaptic plasticitySystemTestingTherapeutic InterventionTimeTobaccoVentral StriatumViralWorkabuse of drugsabused drugabused drugsabuses drugsadeno associated virus groupamygdaloid nuclear complexbacteriophage P1 recombinase Crebiologiccalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcell typedrug abuseddrug of abusedrug seeking behaviordrug/agentdrugs abuseddrugs of abuseelectrophysiologicalendogenous opiateendogenous opioidsendomicroscopyexperienceexperimentexperimental researchexperimental studyexperimentsgain of functiongenetic approachgenetic strategyglutamatergichippocampalimagingin vivoin vivo calcium imaginginterdisciplinary approachintervention therapykappa opiatekappa opioidkappa opioid receptorslead candidatemicroendoscopymouse geneticsmouse modelmultidisciplinary approachmurine modelneural circuitneural circuitryneurocircuitryneuronalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynicotine addictionnicotine consumptionnicotine dependentnicotine rewardnicotine seekingnicotine seeking behaviornicotine self-administrationnicotine treatmentnicotine usenovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachopioid addictionopioid dependenceopioid dependentoptogeneticsparabrachial nucleuspharmacologicpreferencepresynapticreceptorreceptor expressionrecruitsocial rolestriatalsynapsesynaptic circuitsynaptic circuitryviral rescueκ opiateκ opioidκ opioid receptorsκ-ORκOR
Description preview
Despite recent efforts to curb use, nicotine use is at an all time high, is responsible for millions of deaths each year
and remains one of the most difficult drugs to stop using. While there are many reports of opioid receptor, specifically
Kappa-opioid receptor dependent regulation of drug-seeking, there are are still few studies examining the…
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