grant
Dissecting a novel role of FAK in modulating immunity during metastatic reactivation and progression
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20254T1AblationAffectAthymic MiceAthymic Nude MouseBALB C MouseBALB/cBasal Transcription FactorBasal transcription factor genesBindingBiochemistryBiological ChemistryBreast CancerBreast Cancer ModelBreast tumor modelCRISPRCRISPR/Cas systemCancer PatientCancersCause of DeathCell BodyCell Communication and SignalingCell CycleCell Division CycleCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCell modelCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyCellular modelClustered Regularly Interspaced Short Palindromic RepeatsCo-ImmunoprecipitationsDNA Binding DomainDNA TherapyDNA-Binding Protein MotifsDataDevelopmentDimerizationEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEnvironmentEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorFocal Adhesion Kinase 1Gene ExpressionGene Transfer ClinicalGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic InterventionGoalsHumanIFNImmuneImmune EvasionImmune mediated therapyImmune signalingImmunesImmunityImmunobiologyImmunocompetentImmunofluorescenceImmunofluorescence ImmunologicImmunologically Directed TherapyImmunophysiologyImmunotherapyIn VitroInbred BALB C MiceInnate ImmunityIntegrinsIntegrins Extracellular MatrixInterferonsIntracellular Communication and SignalingKinasesLeadMalignant Breast NeoplasmMalignant CellMalignant MelanomaMalignant NeoplasmsMalignant TumorMature T-CellMature T-LymphocyteMediatingMedical centerMelanomaMentorsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiceMice MammalsModelingModern ManMolecular InteractionMurineMusMutateNative ImmunityNatural ImmunityNeoplasm MetastasisNon-Specific ImmunityNonspecific ImmunityNuclear TranslocationNude MiceOncogenesisOutputPTK2 Protein Tyrosine Kinase 2Pathway interactionsPatientsPb elementPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiciansPhysiologicPhysiologicalPrimary NeoplasmPrimary TumorProductionProtacProtein DimerizationProtein PhosphorylationProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProteolysis targeting chimericRNA SeqRNA analysisRNA sequencingRNAseqRelapseResearchRoleSTING agonistsScientistSecondary NeoplasmSecondary TumorSeriesSignal TransductionSignal Transduction SystemsSignalingSiteStrains Cell LinesSubcellular ProcessT-CellsT-LymphocyteTestingTherapeuticTherapeutic InterventionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransducersTransphosphorylasesTumor CellTyrosine KinaseTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseUniversitiesValidationVariantVariationWorkbase editingbiological signal transductioncancer cellcancer metastasiscancer microenvironmentcareercell biologycheck point inhibitioncheckpoint inhibitioncultured cell linedevelopmentalendogenous substrate pp120experimentexperimental researchexperimental studyexperimentsfocal adhesion kinasefocal adhesion protein tyrosine kinasefocal adhesion-associated protein tyrosine kinase pp125FAKgene repair therapygene therapygene-based therapygenetic therapygenomic therapyheavy metal Pbheavy metal leadhydroxyaryl protein kinaseimmune check point inhibitionimmune checkpoint inhibitionimmune competentimmune evasiveimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicin vivoinnate immune pathwaysinsightintervention therapymalignancymalignant breast tumormammary cancer modelmammary tumor modelmouse modelmurine modelneoplasm/cancerneoplastic cellnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayprotein protein interactionproteolysis targeting chimaeraproteolysis targeting chimeraresponsescRNA sequencingscRNA-seqscreeningscreeningsshRNAshort hairpin RNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall hairpin RNAsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthymus derived lymphocytetraining opportunitytranscription factortranscriptome sequencingtranscriptomic sequencingtumortumor cell metastasistumor microenvironmenttumorigenesistyrosyl protein kinasevalidations
Description preview
PROJECT SUMMARY
Metastatic relapse is the dominant cause of death in cancer patients. In many cancers, including breast cancer
and melanoma, metastatic relapse is caused by the reactivation of dormant tumor cells in a manner that permits
immune evasion. However, the mechanisms governing dormancy and immune evasion in incipient metastasis
are…
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