grant
Disruption of the circadian clock in lung cancer
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025ARNTLARNTL geneAccelerationAggressionAggressive behaviorAlveolarAlveolar CellArchitectureAssayAutomobile DrivingAvian Myelocytomatosis Viral Oncogene HomologBMAL1Basal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBiological FunctionBiological ProcessCancersCell BodyCell Communication and SignalingCell CycleCell Cycle ControlCell Cycle RegulationCell Division CycleCell SignalingCell modelCellsCellular modelChromatinCircadian DysregulationCircadian RhythmsCircadian gene expressionCirculationClinicalClinical ResearchClinical StudyComplexCyclicityDNADataDeoxyribonucleic AcidDevelopmentDiseaseDisorderDown-RegulationEndocrine Gland SecretionEngineering / ArchitectureEpithelial CellsEpitheliumExposure toFamilyGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic TranscriptionGlucocorticoid ReceptorGlucocorticoidsGrowthHormonesHourHumanIn VitroIntracellular Communication and SignalingLinkLungLung AdenocarcinomaLung Alveolar EpitheliaLung NeoplasmsLung Respiratory SystemLung TumorMYC geneMalignant CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMammaliaMammalsMediatingMiceMice MammalsModern ManMolecularMolecular InteractionMurineMusNSCLCNSCLC - Non-Small Cell Lung CancerNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaNyctohemeral RhythmOncogene ProductsOncogene ProteinsOncogenesisOncoproteinsOrganoidsPatientsPeriodicityPeripheralProcessPrognosisProliferatingProteinsPulmonary CancerPulmonary NeoplasmsPulmonary malignant NeoplasmRNA ExpressionRepressionResistanceRhythmicityRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSteroid CompoundSteroidsTestingTherapeutic HormoneTimeTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTwenty-Four Hour RhythmUpregulationalveolar epitheliumaryl hydrocarbon receptor nuclear translocator-likebiological signal transductioncancer biomarkerscancer cellcancer markerscancer progressioncell transformationcircadiancircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian processcircadian rhythmicitydaily biorhythmdevelopmentaldisableddrivingexperimentexperimental researchexperimental studyexperimentsexpression subtypesin vivoin vivo Modellung cancerlung cancer cellmalignancymolecular clockmolecular sub-typesmolecular subsetsmolecular subtypesmouse modelmurine modelmyc Oncogenesneoplasm progressionneoplasm/cancerneoplastic progressionontogenyoverexpressoverexpressionpharmacologicpre-clinicalpre-clinical studypreclinicalpreclinical studypreventpreventingpromoterpromotorresistance mechanismresistantresistant mechanismresponserestorationrestraintsocial roletranscription factortransformed cellstumortumor growthtumor progressiontumorigenesis
Description preview
Project Summary
Disruption of the molecular circadian clock is indicative of poor prognosis in non-small cell lung cancers
(NSCLCs), but direct evidence for a causal link between circadian clock deregulation and malignancy in human
cancer is missing. We found that BMAL1 is downregulated in human NSCLCs, indicative of circadian
disruption, low…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click