grant
Disruption of Oral Immune Tolerance by Respiratory Infections: Mechanisms of LungGut Immune Crosstalk
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AffectAgreementAirway infectionsAllergensAllergicAllergic inflammationAllergic to foodAllergy to foodAntigen-Presenting CellsAntigensApoptosisApoptosis PathwayB Cell Differentiation Factor IB blood cellsB cellB cell growth factorB cell growth factor 2B cellsB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Growth Factor-IIB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-CellsB-LymphocytesB-cellBCDF-1BCGFBCGF-1BCGF-IIBCGF2BCSF 1BLR1BLR1 geneBSF-1BSF1Basophilic GranulocyteBasophilsBinetrakinBloodBlood BasophilBlood CirculationBlood EosinophilBlood Plasma CellBlood Reticuloendothelial SystemBloodstreamCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCXCR-5CXCR5Cell DifferentiationCell Differentiation processCirculationClass SwitchingClass SwitchingsDendritic CellsDevelopmentDietary ProteinsDiseaseDisorderDistalEducationEducational aspectsEffector CellEnvironmental FactorEnvironmental Risk FactorEo-CSFEosinophil Differentiation FactorEosinophilic GranulocyteEosinophilic LeukocyteEpitheliumExhibitsFailureFoodFood AllergyFood HypersensitivityGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGerminal CenterGoalsGrippeGut EpitheliumHealth Care CostsHealth CostsHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteIL-13IL-4IL-5IL13IL4 ProteinIgA enhancing factorIgEImmuneImmune ToleranceImmune responseImmune systemImmunesImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsImmunoglobulin EImmunologic ToleranceImmunomodulationIndividualInducer CellsInducer T-LymphocytesInfluenzaIngestionInherited PredispositionInherited SusceptibilityInterleukin 5 PrecursorInterleukin-13Interleukin-4Interleukin-4 PrecursorInterleukin-5Isotype SwitchingIsotype SwitchingsLearningLifeLocationLungLung InflammationLung Respiratory SystemLymphocyte Stimulatory Factor 1MCGF-2MDR15Marrow EosinophilMarrow Mast CellMast Cell Growth Factor-2Mediastinal Lymph NodeMediastinal lymph node groupMolecularMorbidityMorbidity - disease rateOralOral AdministrationOral Drug AdministrationOrganism-Level ProcessOrganismal ProcessOvalbuminPD 1PD-1PD1PathogenesisPathogenicityPeripheralPhenotypePhysiologic ProcessesPhysiological ProcessesPlasma CellsPlasmacytesPlayPneumonitisProductionProgrammed Cell DeathProteinsPublic HealthPulmonary InflammationRegulatory T-LymphocyteResearchRespiratory InfectionsRespiratory Tract InfectionsRoleShapesSiteStructure of germinal center of lymph nodeT cell replacing factorT-Cell Growth Factor 2T-Cell Replacing FactorT-CellsT-LymphocyteT4 CellsT4 LymphocytesTissue BasophilsTregVeiled CellsViral Respiratory Tract InfectionWorkaccessory cellairway epithelium inflammationairway inflammationcellular differentiationcytokinedevelopmentaldietarydietary restrictionearly childhoodenvironmental riskeosinophilflu infectionflu virus infectionfood antigengastrointestinal epitheliumgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedhost responseimmune modulationimmune regulationimmune system responseimmune system toleranceimmune unresponsivenessimmunogenimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinfancyinfantileinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza virus infectioningestintraoral drug deliverymast cellmastocytemesenteric lymph nodemesentery lymph nodemicrobial consortiamicrobial floramicrobiotamicrofloramultispecies consortianoveloral tolerancepatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesplasmocytepreventpreventingprogrammed cell death 1programmed cell death protein 1programmed death 1recruitregulatory T-cellsrespiratoryrespiratory inflammationrespiratory tract inflammationresponserestricted dietsle2social rolesystemic lupus erythematosus susceptibility 2thymus derived lymphocyteviral respiratory infection
Description preview
Food allergies are a growing public health concern, associated with significant morbidity, dietary restrictions, and rising healthcare costs. These disorders arise when the immune system mounts an inappropriate response to otherwise harmless dietary proteins, typically characterized by the production of allergen-specific IgE and the activation of…
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