grant
Disentangling the HIV/opioid intertwined mechanisms on mitochondrial mediated inflammasome activation, neurotoxicity and targeting strategies: In vivo and in vitro analyses of fresh human brain
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 15 Apr 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAltruismAmmon HornAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAnti-Retroviral AgentsAntibodiesAntinociceptive AgentsAntinociceptive DrugsApoptosis-Related Cysteine Protease Caspase 1ArchivesAssayAutopsyBasal GangliaBasal NucleiBeta Proprotein Interleukin 1BioassayBiological AssayBiometricsBiometryBiostatisticsBody TissuesBrainBrain Nervous SystemBrain regionCASP-1CASP1CASP1 geneCNS Nervous SystemCaspase-1Caspase-1 GeneCell BodyCell Culture TechniquesCellsCentral Nervous SystemCessation of lifeChronicCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionComplexConsequences of HIVCornu AmmonisDataDeathDevelopmentDisturbance in cognitionEncephalonEnrollmentEvaluationExhibitsExposure toFreezingGC MSGCMSGas-Liquid-Mass Spectrometry ChromatographyGene TranscriptionGenetic TranscriptionGiftsGoalsHIVHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV InfectionsHIV env Protein gp120HIV related cognitive dysfunctionHIV related cognitive impairmentHIV-associated cognitive dysfunctionHIV-associated cognitive impairmentHTLV-III InfectionsHTLV-III gp120HTLV-III-LAV InfectionsHealthHealth PromotionHippocampusHistoryHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsICE ProteaseIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 betaIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1 βIL-1-bIL-18IL-18 GeneIL-1BCIL-1b Converting EnzymeIL-1gIL-1g GeneIL-1βIL1-BetaIL1-βIL18IL18 ProteinIL18 geneIL1B ProteinIL1B-ConvertaseIL1BCIL1BCEIL1F2IL1F4IL1F4 GeneIL1βImmunoblottingImpaired cognitionIn VitroIndividualInflammasomeInflammationInfumorphInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1betaInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 betaInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-1βInterventionInvestigationKadianKnowledgeLAV-HTLV-IIILong-term infectionLymphadenopathy-Associated VirusMGC12320MGC12320 GeneMS ContinMSirMass FragmentographiesMass FragmentographyMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMass-Gas Chromatography SpectrometryMass-Gas Chromatography Spectrum AnalysisMeasuresMediatingMediatorMethodologyMicroscopicMitochondriaModelingModern ManMorphiaMorphineMyeloid CellsNerve CellsNerve DegenerationNerve UnitNeural CellNeuraxisNeurocyteNeurologicNeurologicalNeuron DegenerationNeuronsNeuropsychologiesNeuropsychologyNon-Polyadenylated RNAOccipital lobeOpiatesOpioidOramorphOramorph SROutcomeParietal LobeParticipantPathway interactionsPatternPersonsPharmacologyPreinterleukin 1 BetaProteinsRNARNA ExpressionRNA Gene ProductsRNA SplicingRecording of previous eventsResearchResearch SpecimenRibonucleic AcidRoxanolSalutogenesisShort interfering RNASmall Interfering RNASpecimenSplicingStatex SRTherapeuticTissuesTranscriptionTubulinViralVirus-HIVWestern BlottingWestern Immunoblottingaltruisticanti-retroviralantiretroviral therapyantiretroviral treatmentbrain cellbrain tissuecatalystcell culturecell cultureschronic infectioncognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingcohortdevelopmentalenrollextracellularfrontal cortexfrontal lobegp120gp120 ENV Glycoproteingp120(HIV)hippocampalhistoriesimprovedin vitro Modelin vivoinsightion trap mass spectrometryknock-downknockdownlicit opioidmass fragmentometrymilligrammitochondrialnecropsyneural degenerationneural inflammationneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneuron toxicityneuronalneuronal degenerationneuronal toxicityneuropathologicneuropathologicalneuropathologyneuroprotectionneuroprotectiveneuropsychologicneurotoxicneurotoxicityoccipital cortexopiate consumptionopiate drug useopiate exposureopiate intakeopiate medicationopiate useopioid consumptionopioid drug useopioid exposureopioid intakeopioid medicationopioid usepain killerpain medicationpain relieverpainkillerparietal cortexparticipant enrollmentpathwaypatient enrollmentpersistent infectionpostmortemprescribed opiateprescribed opioidprescription opiateprescription opioidpromoting healthprotein blottingresponsesiRNAsmall moleculesynergismvirology
Description preview
Summary.
Despite effective antiretrovirals (ARV), Human Immunodeficiency Virus (HIV) spreads within the central nervous
system (CNS) and establishes persistent infection precipitating cognitive impairment (CI). Recent findings
suggest that HIV protein (namely VPR) expression in the brain activates the inflammasome pathway in neurons
leading to…
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