grant
Disentangling the biological links between violence and alcohol use
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Jun 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202612-20 years old5-HT5-Hydroxytryptamine5HTACTH-Releasing FactorAcuteAdolescenceAdverse effectsAggressionAggressive behaviorAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAllelesAllelomorphsAngerAnimal ModelAnimal Models and Related StudiesAnimalsBehavioralBiologicalCRF receptor type 1CRF-41CRF-R1CRF1 receptorCRH-1Cell Communication and SignalingCell SignalingChild Abuse and NeglectChildhood maltreatmentClinicalComplexCorticoliberinCorticotropin-Releasing FactorCorticotropin-Releasing Factor-41Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone-41Crh1 receptorDNA mutationDataDevelopmentDopamineDoseEconomic BurdenElectrophysiologyElectrophysiology (science)EnteramineEnzyme GeneEnzymesEtOH drinkingEtOH useFemaleGene x Environment InteractionGenesGenetic CarriersGenetic ChangeGenetic defectGenetic mutationGenotypeGlutamate ReceptorGxE interactionHippophaineHistoryHumanHydroxytyramineImpairmentIndividualIntracellular Communication and SignalingLifeLinkMAO-AMiceMice MammalsModelingModern ManMonoamine Oxidase AMurineMusMutationN Methyl D aspartic AcidN methyl D aspartateN-Methyl-D-aspartateN-MethylaspartateNMDANerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNucleus AccumbensPathologicPatternPrefrontal CortexPreventionProcessReceptor ActivationRecording of previous eventsRecurrenceRecurrentRegimenResearchSerotoninShapesSignal TransductionSignal Transduction SystemsSignalingSliceTestingTimeTransmissionType A Monoamine OxidaseVariantVariationViolenceabused drugabused drugsadolescence (12-20)alcohol abuse therapyalcohol abuse treatmentalcohol and other drugalcohol co-morbidityalcohol comorbidityalcohol effectalcohol ingestionalcohol intakealcohol misusealcohol preventionalcohol product usealcohol reinforcementalcohol rewardalcohol riskalcohol treatmentalcohol usealcoholic beverage consumptionalcoholic drink intakeallele carriersangersangryantagonismantagonistbiologicbiological signal transductionchild maltreatmentco-morbidco-morbiditycomorbidityconditioned place preferencecorticotropin releasing hormonecorticotropin-releasing factor receptor 1developmentaldrug abuseddrug of abusedrugs abuseddrugs of abuseearly life exposureearly life stresseconomic impactelectrophysiologicalenvironment effect on geneethanol consumptionethanol drinkingethanol effectethanol ingestionethanol intakeethanol misuseethanol product useethanol reinforcementethanol rewardethanol usegene environment interactiongenome mutationhigh riskhistoriesmalemodel of animalmutantneurobiological mechanismneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyplace conditioningpostnatalpreferencepupreceptor functionreinforced behaviorsocialsocio-economicsocio-economicallysocioeconomicallysocioeconomicstransmission processunhealthy alcohol useviolentviolent behavior♀♂
Description preview
PROJECT SUMMARY/ABSTRACT
Alcohol misuse is often associated with pathological aggression, a recurrent pattern of disruptive and violent
behavior. Despite the significant socioeconomic burden imposed by the repercussions of this comorbidity, avail-
able treatments are limited and inadequate. A critical problem in treating the association of alcohol…
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