grant

Disease Mechanisms of Early Pulmonary Fibrosis

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 17 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025Airway failureAtlasesAutomobile DrivingBiologicalBiological MarkersBiopsyBloodBlood Reticuloendothelial SystemBody TissuesBronchioalveolar LavageBronchoalveolar LavageBronchopulmonary LavageCausalityCell BodyCellsCessation of lifeChemicalsCicatrixClinicalCohort StudiesConcurrent StudiesDataDeathDevelopmentDiseaseDisease ProgressionDisorderDistalDysfunctionEarly identificationEnvironmentEnvironmental ExposureEnvironmental ToxinEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpigenetic ageEpitheliumEtiologyEvaluationEventFunctional disorderFutureGasesGene TranscriptionGeneticGenetic DiversityGenetic PredispositionGenetic Predisposition to DiseaseGenetic RiskGenetic SusceptibilityGenetic TranscriptionGenetic VariationGenetic propensityGenomicsGoalsImageIn SituInherited PredispositionInherited SusceptibilityInjuryInterventionKnowledgeLengthLungLung Alveolar EpitheliaLung LavageLung Respiratory SystemLung Tissue FibrosisMeasuresMediatingMetabolicMetalsModelingMolecularMorbidityMorbidity - disease rateMotionNatural HistoryNatureOrganoidsPathogenesisPatientsPhenotypePhysiopathologyPreventionPulmonary FibrosisQTLQuantitative Trait LociRNA ExpressionRelative RisksRespiratory EpitheliumRespiratory FailureRiskRisk-associated variantScarsServicesShapesStandardizationStimulusStructure of respiratory epitheliumSymptomsTechnologyTestingTherapeuticTimeTissuesToxic Environmental AgentsToxic Environmental SubstancesTranscriptionWorkairway epitheliumalveolar epitheliumbio-markersbiologicbiologic markerbiomarkerbronchiolar alveolar lavagebronchopulmonary lavage therapycausationcell typecohortdata acquisitiondata acquisitionsdevelopmentaldisease causationdisease modeldisease preventiondisorder modeldisorder preventiondrivingenvironmental toxicantepigeneticallyepithelial injuryepithelial repairexposomefibrosis in the lungfunctional genomicsgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedhuman subjectimagingimprovedinjuriesinjury responseinsightinterstitiallung fibrosismortalitymultiomicsmultiple omicsnew approachesnovelnovel approachesnovel strategiesnovel strategypanomicspathophysiologypre-clinicalpreclinicalpreventpreventingprogramsrepairrepairedrespiratory tract epitheliumresponseresponse to injuryrisk allelerisk generisk genotyperisk locirisk locusrisk stratificationrisk variantspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstratify risktelomeretranscriptome profilingtranscriptomic profilingtranscriptomicstreatment strategy
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PROGRAM PROJECT SUMMARY
To develop novel, transformative therapies that substantially reduce the burden of morbidity and mortality from

progressive pulmonary fibrosis (PF), a fundamentally new conceptualization of PF is required. It is becoming

clear that lung fibrosis is a consequence, rather than the primary driver, of disease pathobiology and…

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Disease Mechanisms of Early Pulmonary Fibrosis — UNIVERSITY OF MICHIGAN AT ANN ARBOR | UNITED STATES | Sept 2024 | Dev Procure