grant
Discovery of GPR52 ligand probes for cocaine use disorder
Organization UNIVERSITY OF TEXAS MED BR GALVESTONLocation GALVESTON, UNITED STATESPosted 1 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY202521+ years old3'5'-cyclic ester of AMP3,5 cyclic AMP synthetaseAbbreviationsAddressAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)Adenyl CyclaseAdenylate CyclaseAdenylyl CyclaseAdultAdult HumanAffinityAgonistAmphetaminesArrestinsAssayBehaviorBehavioralBindingBioassayBiological AssayBody TissuesBrainBrain Nervous SystemCRE Binding ProteinCREBCREB ProteinCREB1CREB1 geneCell Communication and SignalingCell SignalingCellular AssayChemicalsCocaineCocaine misuseCocaine use disorderCommon Rat StrainsCorpus StriatumCorpus striatum structureCoupledCrystal MethCrystal methamphetamineCyclic AMPCyclic AMP Response Element-Binding ProteinCyclic AMP Responsive Element Binding ProteinCyclic AMP-Dependent Protein KinasesCyclic AMP-Responsive DNA-Binding ProteinD2 receptorDRD2 ReceptorData BasesDatabasesDeoxyephedrineDesoxyephedrineDesoxynorephedrinDevelopmentDiagnosisDiseaseDisorderDopamineDopamine D2 ReceptorDrug KineticsDrug Synthesis and ChemistryDrugsElectrophysiologyElectrophysiology (science)EncephalonEnsureExperimental TherapiesG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG(s), alpha SubunitG(s), α SubunitG(s)alphaG(s)αG-Protein-Coupled ReceptorsG-ProteinsGPCRGTExGTP-Binding Protein alpha Subunits, GsGTP-Binding Protein α Subunits, GsGTP-Binding ProteinsGTP-Regulatory ProteinsGene TranscriptionGenetic TranscriptionGenotypeGenotype-Tissue Expression ProjectGoalsGs alpha Family G-ProteinGsαGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGαsHealthHigh Throughput AssayHumanHydroxytyramineIn VitroInformaticsIntracellular Communication and SignalingIntracellular Second MessengerInvestigational TherapiesInvestigational TreatmentsLeadLigandsLightLinkLocomotor ActivityMaintenanceMedicalMedicationMetabolicMethamphetamineMethamphetamine use disorderMethylamphetamineMiceMice MammalsModern ManMolecular InteractionMotor ActivityMurineMusN-MethylamphetamineNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNucleus AccumbensOrphanPKAPathway interactionsPatientsPb elementPersonsPharmaceutical PreparationsPharmacodynamicsPharmacokineticsPharmacologyPhenaminePhenoprominPhotoradiationPhysiologicPhysiologicalPre-Clinical ModelPreclinical ModelsProcessProductionProtein Kinase APublic HealthRNA ExpressionRatRats MammalsRattusReceptor ProteinRegulatory Ns ProteinRetinal S-AntigenRewardsRodentRodentiaRodents MammalsScientific Advances and AccomplishmentsSecond Messenger SystemsSecond MessengersSelf AdministeredSelf AdministrationSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSliceStimulantStimulatory Gs G-ProteinStriate BodyStriatumStructure-Activity RelationshipSubstance Use DisorderSystemTherapeuticTissuesTranscriptionTranslational ResearchTranslational ScienceTreatment EfficacyUnited StatesValidationVentral Tegmental AreaVulnerable Populationsadenosine 3'5' monophosphateadulthoodagedalpha Subunit Stimulatory GTP-Binding Proteinalpha-Gsarrestin Baxon signalingaxon-glial signalingaxonal signalingbehavior phenotypebehavioral phenotypingbeta-arrestinbiological signal transductioncAMPcAMP Response Element-Binding ProteincAMP Response Element-Binding Protein 1cAMP Responsive Element Binding ProteincAMP-Dependent Protein Kinasescell assaychemical structure functionclinical applicabilityclinical applicationclinical significanceclinically significantdata basedesensitizationdesigndesigningdevelopmentaldl-Amphetaminedrug metabolismdrug synthesisdrug/agentelectrophysiologicalexperimentexperimental researchexperimental studyexperimental therapeutic agentsexperimental therapeuticsexperimentsglia signalingglial signalingheavy metal Pbheavy metal leadhigh throughput screeningin vivoin vivo Modelintervention efficacymedication-assisted therapymedication-assisted treatmentmethmeth use disordernerve signalingneural circuitneural circuitryneural controlneural regulationneural signalingneurocircuitryneuromodulationneuromodulatoryneuronalneuronal excitabilityneuronal signalingneuropsychiatric diseaseneuropsychiatric disorderneuroregulationneurotransmissionnovelobject recognitionpathwaypre-clinicalpre-clinical studypreclinicalpreclinical studyprescription stimulantsprogramspsychologicpsychologicalpsychostimulant abusepsychostimulant misusepsychostimulant use disorderradioligandreceptorscaffoldscaffoldingscientific accomplishmentsscientific advancessignal transduction second messengerssmall moleculestimulant abusestimulant misusestimulant use disorderstriatalstructure function relationshipsubstance use and disordersynaptic circuitsynaptic circuitrytherapeutic efficacytherapeutic targettherapy efficacytooltranslation researchtranslational investigationvalidationsventral tegmentumvulnerable groupvulnerable individualvulnerable peopleα-Gsβ-arrestin
Description preview
PROJECT SUMMARY
Abuse of psychostimulants represents a major public health problem in the United States. Continued misuse of
stimulants escalates in vulnerable individuals to a substance use disorder (SUD). SUDs are debilitating
conditions evidenced by sustained, clinically significant health consequences and there is a critical unmet need
to…
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