grant
Discovery of genes required for expression or activity of fusion oncogenes
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAdhesion PlaquesAffinityAreaAssayAvian Erythroblastosis virus E26 (v-ets) oncogene homolog-1Basal Transcription FactorBasal transcription factor genesBindingBioassayBiochemicalBiological AssayBone CancerBone TissueCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCancer BiologyCancer GenesCancer TreatmentCancer-Promoting GeneCancersCategoriesCell BodyCell Communication and SignalingCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell membraneCell-Matrix Adherens JunctionsCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessChimera ProteinChimeric ProteinsChromosomesClinicalCytoplasmic MembraneCytotoxic ChemotherapyCytotoxic TherapyDNADNA Polymerase IIDNA Polymerase epsilonDNA-Dependent DNA Polymerase IIDataDeoxyribonucleic AcidDependenceDesmoplasticDesmoplastic ReactionDetectionDevelopmentDiseaseDisease ProgressionDisorderDistantDreamsDrug TherapyDysfunctionERGB Transcription FactorETS1ETS1 geneEWSR1EWSR1 geneEWSR2EventEwing Sarcoma Breakpoint Region 1Ewing Sarcoma Breakpoint Region 2Ewing's Family of TumoursEwing's Sarcoma/Peripheral Primitive Neuroectodermal TumorEwing's TumorEwings sarcomaExclusionExhibitsExonsExposure toF-ActinFLI1FLI1 ProteinFLI1 Transcription FactorFLI1 geneFLJ10768Filamentous ActinFli-1 proto-oncogene, ETS transcription factorFocal AdhesionsFocal ContactsFollow-Up StudiesFollowup StudiesFriend Leukemia Virus Integration 1 ProteinFriend Leukemia Virus Integration 1 Transcription FactorFriend leukemia virus integration 1Functional disorderFusion Oncogene ProteinsFusion ProteinG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGene Action RegulationGene DeregulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic TranscriptionGrowthGuanineHealthHeterogeneous-Nuclear RibonucleoproteinsHuman ChromosomesIlluminationImageIndividualInformoferIntervening SequencesIntracellular Communication and SignalingIntronsInvestigationInvestigational DrugsInvestigational New DrugsKnowledgeLightingMalignant Bone NeoplasmMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Osseous NeoplasmMalignant Osseous TumorMalignant Soft Tissue NeoplasmMalignant TumorMalignant Tumor of the BoneMediatingMessenger RNAMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMicroscopyMolecular CarcinogenesisMolecular InteractionMolecular TargetMovementNeoplasm MetastasisNeoplasmsNeural Crest CellNon-Polyadenylated RNANpl3NuclearNucleic Acid BindingNucleic AcidsNucleoplasmOncogene DeregulationOncogenesOncogenesisOncogenicOperative ProceduresOperative Surgical ProceduresOsseous CancerPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmacological TreatmentPharmacotherapyPhenotypePhosphorylationPhysiopathologyPlasma MembranePol IIPost-Transcriptional ControlPost-Transcriptional Gene SilencingPost-Transcriptional RegulationPost-Translational RegulationPosttranslational RegulationPre-mRNAProcessProliferatingPromoter RegionsPromotor RegionsPropertyProtein FamilyProtein PhosphorylationProteinsPublishingRBP56RNARNA BindingRNA ExpressionRNA Gene ProductsRNA InterferenceRNA ProcessingRNA SilencingRNA SplicingRNA TransportRNA boundRNA interference screenRNA metabolismRNA, Messenger, PrecursorsRNAiRNAi screenRNAi-based screenRadiationRefractoryRelapseReportingRepressionResearchResolutionReverse TranscriptionRibonucleic AcidRibonucleic Acid TransportRiskSIC-1SarcomaSecondary NeoplasmSecondary TumorSequence-Specific Posttranscriptional Gene SilencingSeriesSignal TransductionSignal Transduction SystemsSignalingSiteSmall RNASplicingStimulusStrains Cell LinesStructureSubcellular ProcessSurgicalSurgical InterventionsSurgical ProcedureSurvival RateTAF15TAF15 geneTAF2NTechnologyTissue GrowthTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransforming GenesTranslationsTranslocation BreakpointTumor BiologyTumor CellUpregulationVariantVariationVinculinVisualizationWorkactivating CRISPR technologyanti-cancer therapybiological signal transductionbody movementcancer cellcancer metastasiscancer therapycancer-directed therapyclinical relevanceclinically relevantcohortcombinatorialcompare to controlcomparison controlcultured cell linedesigndesigningdevelopmentaldiscover genesdrug interventiondrug treatmentfunctional genomicsfusion genefusion oncoproteingene discoverygenetic promoter elementgenetic promoter sequencegenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehTAFII68hnRNPimagingimproved outcomelater in lifelater lifeliposarcomaloss of functionmRNAmRNA Precursormalignancymalignant soft tissue tumormembermetavinculinneoplasianeoplasm/cancerneoplastic cellneoplastic growthnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetnucleic acid binding proteinontogenypathophysiologypathwaypatient oriented outcomespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsplasmalemmapost-transcriptional gene regulationposttranscriptionalprogenitorpromoter sequenceprotein functionrecruitresolutionsresponseresponse to therapyresponse to treatmentscaffoldscaffoldingsoft tissuestandard carestandard treatmentsuperresolution microscopysurgerytherapeutic responsetherapy responsetranscription factortranscriptometranslationtreatment responsetreatment responsivenesstumortumor cell metastasistumorigenesisv-ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1
Description preview
EWSR1's functions at the intersection of transcription and RNA processing: Proteins categorized as hnRNPs have diverse functions critical to the regulation of transcription, RNA processing and RNA transport, translation, and turnover. FUS, EWSR1, and TAF15, the FET family of proteins are multifunctional hnRNPs that function in transcriptional…
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