grant
Discovery of Antibiotics from Soil Microbiomes Using Metagenomics
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 May 2017Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Antibiotic AgentsAntibiotic DrugsAntibioticsBacteriaBacterial natural productsBacterial-derived natural productBase SequenceBioinformaticsCloningCulture-independent methodsDNADeoxyribonucleic AcidDevelopmentDiseaseDisorderDrug ScreeningEnvironmentFinding natural productsFunctional MetagenomicsGene ClusterGenomicsGoalsHistoryIndustrializationLaboratoriesLeadLeftMDR organismMDR pathogenMedicalMetagenomicsMethodsMiscellaneous AntibioticMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantNatural HistoryNatural ProductsNatural product discoveryNatural products from bacteriaNatureNucleotide SequencePb elementProductivityRecording of previous eventsResearchResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugSamplingSoilSourceStructureSurfaceWorkbioactive natural productsclinical relevanceclinically relevantculture-independent analysesculture-independent approachesculture-independent molecular techniquesculture-independent techniquesdesigndesigningdevelopmentalheavy metal Pbheavy metal leadhistoriesmetagenomemethod developmentmicrobiomemulti-drug resistantmulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistantmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogennaturally occurring productnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynucleic acid sequencepathogenprogramsscreeningscreeningssmall moleculesuccess
Description preview
Project Summary:
Bacterial natural products have a long history of serving as lead structures for the development of new
therapeutically relevant small molecules. Despite the tremendous early success of bacterial natural product
discovery programs, both academic and industrial drug screening efforts have largely deprioritized natural
products in…
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