grant

Discovering lipid transport mechanisms in Mycobacterium tuberculosis

Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 20 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AddressAffectAnalytic ChemistryAnalytical ChemistryAntigensAntitubercular DrugsAutoregulationAwardBiochemicalBostonCarbonCatabolismCause of DeathCell Surface AntigensCell surfaceCholesterolChromatographyClinicalCollaborationsCommunitiesComplexDataDefectDevelopmentDiagnosisDiagnosticDrug TargetingEducational process of instructingElectron MicroscopyEnvironmentEnzyme GeneEnzymesFundingGeneralized GrowthGenesGeneticGenus MycobacteriumGlycansGoalsGrowthHomeostasisHospitalsHumanImmune systemImmunityImmunological Surface MarkersInfectionInfectious AgentInvestigationKnowledgeLabelLaboratoriesLinkLipid TraffickingLipidsM smegmatisM tbM tuberculosisM tuberculosis infectionM. smegmatisM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMentorsMethodsMicellesModern ManMycobacteriumMycobacterium smegmatisMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNatureOxidation-ReductionOxidative StressPathogenesisPathogenicity FactorsPathway interactionsPeriplasmic SpacePersonsPhasePhysiologicPhysiologicalPhysiological HomeostasisPlayPolysaccharidesPopulationPostdocPostdoctoral FellowPreventionProteinsPublic Health SchoolsPublicationsRedoxResearchResearch AssociateRoleScientific PublicationServicesShapesSourceSurfaceSurface AntigensSystemTB drugsTB infectionTeachingTeaching HospitalsTechniquesTestingTissue GrowthTrainingTransmissionTuberculosisVaccinesVirulence FactorsWomanWorkanti-TB drugsanti-tuberculosis drugsaqueousbacterial fitnesscareercell envelopecomparativedevelopmentaldisseminated TBdisseminated tuberculosisextracellularhuman diseasehuman pathogenimmunogenimprovedin vivoinfection due to Mycobacterium tuberculosisinfectious organismlipid transportlipidomelipidomicsloss of function mutationmedical collegemedical schoolsmembrane structuremtbmycobacterialnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyoxidation reduction reactionpathogenpathwayperiplasmpost-docpost-doctoralpost-doctoral traineeresearch associatesschool of medicineskillssocial roletooltransmission processtuberculosis drugstuberculosis infectiontuberculous spondyloarthropathy
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PROJECT SUMMARY: Mycobacterium tuberculosis (Mtb) is the leading cause of death worldwide due to a
single pathogen. Mtb is exceptionally reliant on specialized lipids, yet little is known about how lipids and lipid-

linked glycans transit across the membranes and aqueous periplasm of mycobacteria. My objective is to reveal

how Mtb controls the…

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Discovering lipid transport mechanisms in Mycobacterium tuberculosis — BRIGHAM AND WOMEN'S HOSPITAL | UNITED STATES | Ap | Dev Procure