grant
Differentiation balances oncogene-driven proliferation to maintain epidermal homeostasis
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 27 Jul 2017Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20252-photon microscopy21+ years oldAdultAdult HumanAssayAutomobile DrivingAutoregulationBehaviorBioassayBiological AssayBiologyBlood VesselsBody TissuesCancer GenesCancer-Promoting GeneCancersCell BodyCell Communication and SignalingCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCellsCommunicationCuesDNA DamageDNA InjuryDNA mutationDataDermalDevelopmentEngineeringEngraftmentEnsureEnvironmental HazardsEph Receptor LigandsEphrinsEpidermisEpistasisEpistatic DeviationEpithelial CellsEpitheliumEquilibriumExposure toFailureFutureGene TargetingGeneralized GrowthGenetic ChangeGenetic EpistasisGenetic defectGenetic mutationGenotoxinsGoalsGrowthHealthHomeostasisHumanImmunofluorescenceImmunofluorescence ImmunologicInteraction DeviationIntracellular Communication and SignalingLifeLigandsMaintenanceMalignant NeoplasmsMalignant TumorMediatingMethodsMiceMice MammalsModern ManMolecularMurineMusMutagensMutateMutationNeighborhoodsNormal CellOncogenesOncogenesisOncogenicPathogenicityPathologicPathway interactionsPatternPhenotypePhysically ChallengedPhysiological HomeostasisProgenitor CellsProliferatingPublishingReceptor ProteinRegulationResearchSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSkinStromal CellsTechnologyTestingTherapeuticTissue GrowthTissuesTransforming GenesWild Type MouseWorkadulthoodaxon growth cone guidanceaxon guidancebalancebalance functionbiological signal transductioncancer progenitorcancer progenitor cellscancer stem cellcancer stem like cellcell typedevelopmentaldriver lesiondriver mutationdrivingepidermal progenitorepidermal progenitor cellepidermal stem cellepistatic interactionepistatic relationshipfrontiergain of functiongene functiongene x gene interactiongenetic epistasesgenome mutationgenotoxic agentimprovedinnovateinnovationinnovativeintercellular communicationintervention designintra-vital imagingintravital imagingloss of functionmalignancymalignant progenitormalignant stem cellmouse modelmurine modelneoplasm/cancernoveloncogenic progenitoroncogenic stem cellsontogenypathwaypostmitoticpreventpreventingprogenitorprogenitor Cell growthprogenitor cell differentiationprogenitor cell divisionprogenitor cell fateprogenitor cell poolprogenitor cell populationprogenitor cell renewalprogenitor differentiationprogenitor divisionprogenitor fateprogenitor growthprogenitor like cancer cellprogenitor poolprogenitor populationprogenitor renewalproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialreceptorresponseself-renewself-renewalstem and progenitor cell divisionstem and progenitor cell fatestem and progenitor cell populationstem and progenitor cell renewalstem and progenitor differentiationstem cell differentiationstem cell divisionstem cell fatestem cell growthstem cell poolstem cell populationstem cell renewalstem cellsstem like cancer cellsynergismtherapy designtreatment designtumorigenesistwo photon excitation microscopytwo photon microscopyvascularwildtype mouse
Description preview
Project Summary
In skin epithelium, a population of progenitor cells distinctly capable of proliferation, self-renewal, and terminal
differentiation into post-mitotic progeny, is responsible to sustain tissue homeostasis throughout life. In particular,
the dynamic choice between renewal and differentiation has emerged as a critical regulator of…
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