grant
Differentiating the biological effects of vaping from smoking by analyzing the methylome and transcriptome
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 15 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAberrant DNA MethylationAccountingAdultAdult HumanAffectAssayBS-seqBenefits and RisksBioassayBiochemicalBioinformaticsBiologicalBiological AssayBiological MarkersBiological Specimen BanksBiological Substance BanksBisulfite-based sequencingBlood CellsBlood leukocyteBody TissuesCancer Causing AgentsCarcinogensCell BodyCellsCharacteristicsChemicalsCigaretteCigarette SmokerComputer ModelsComputerized ModelsDNA MethylationDataData AnalysesData AnalysisData SetDevicesDietDiseaseDisorderDoseElectronic cigaretteEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvaluationFundingGene TranscriptionGeneral PopulationGeneral PublicGenerationsGenesGenetic TranscriptionHealthHumanLaboratoriesLeukocytesLeukocytes Reticuloendothelial SystemLife StyleLifestyleLinkMarrow leukocyteMeasurementMeasuresMethylationModelingModern ManMolecularNIDCRNIDRNational Institute of Dental ResearchNational Institute of Dental and Craniofacial ResearchNetwork AnalysisNicotineOncogensOntologyOralPathway AnalysisPathway interactionsPatternPeripheral Blood CellPopulationProcessPublic HealthRNA ExpressionRNA SeqRNA analysisRNA sequencingRNAseqResearchResearch SpecimenRiskSafetyScienceSmokerSmokingSmoking HistorySmoking StatusSourceSpecimenStudy SubjectTarsTissuesTobaccoTobacco ConsumptionTobacco useTranscriptionTranslatingValidationWhite Blood CellsWhite Celladulthoodbio-markersbiologicbiologic markerbiological specimen repositorybiomarkerbiomarker identificationbiosample repositorybiospecimen bankbiospecimen repositorybisulfite sequencingbisulfite-seqcell typecigarette smokecigarette smokingcigarette usecombustible cigarettecompare to controlcomparison controlcomputational modelingcomputational modelscomputer based modelscomputerized modelingconventional cigarettedata interpretationdemographicsdietsdifferential expressiondifferentially expresseddisease riskdisorder riske-cige-cig aerosolse-cig liquidse-cig usee-cig usere-cig vapore-cigarettee-cigarette aerosolse-cigarette liquidse-cigarette usee-cigarette usere-cigarette vapore-juicee-liquidecigecig aerosolsecig liquidsecig useecig userecig vaporecigaretteecigarette aerosolsecigarette liquidsecigarette useecigarette userecigarette vaporejuiceelectronic cigarette aerosolelectronic cigarette useelectronic cigarette userelectronic cigarette vaporelectronic liquideliquidentire genomeepigeneticallyfull genomegene networkgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehealth assessmentidentification of biomarkersidentification of new biomarkersinnovateinnovationinnovativemarker identificationmethylomemodel buildingnew approachesnew markernovel approachesnovel biomarkernovel markernovel strategiesnovel strategyoncogenic agentpack/yearpathwaypatient populationperipheral bloodpreservationpublic health relevanceregulate tobaccosegregationspecimen bankspecimen repositorytobacco product usetobacco productstobacco regulationtobacco regulatory effortstoxicanttraditional cigarettetranscriptional differencestranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsvalidationsvapervapingwhite blood cellwhite blood corpusclewhole genome
Description preview
Responsiveness to NOT-OD-22-022: This proposal will segregate the biological effects of electronic cigarette
(e-cig) use (‘vaping’) from smoking by measuring the epigenetic and transcriptomic changes linked to risk of
disease in cells and tissues of healthy adult vapers and/or cigarette smokers as compared to controls (non-users
of either…
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