grant
Differential changes in energy metabolism in response to mechanical tension give rise to human scaring heterogeneity
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Jul 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025ActinsAddressBioenergeticsBiologic ModelsBiological ModelsBiomechanicsBone-Derived Transforming Growth FactorCSAID-Binding Protein 1CSAID-Binding Protein 2CSBP2CancersCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCell-Extracellular MatrixCellsCellular MatrixCellular MechanotransductionCellular ProliferationChaperoneCicatrixClinicalCollagenCommunicationCytokine-Suppressive Antiinflammatory Drug-Binding Protein 1Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2Cytoskeletal SystemCytoskeletonDataDepositDepositionDermalDermal injuryDevelopmentDimerizationDiseaseDisorderECMEconomic BurdenEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzymesExtracellular MatrixFibroblastsFibrosisFoundationsGlycolysisHealth CareHeterogeneityHeterograftHeterologous TransplantationHumanIn VitroIndividualInflammatoryInjuryIntermediary MetabolismIntracellular Communication and SignalingInvadedKinasesKnowledgeLeadLinkMAPK14MAPK14 Mitogen-Activated Protein KinaseMAPK14 geneMalignant NeoplasmsMalignant TumorMechanical Signal TransductionMechanicsMechanosensory TransductionMediatingMediatorMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsMilk Growth FactorMitochondriaMitogen-Activated Protein Kinase 14Model SystemModern ManMolecular ChaperonesMorbidityMorbidity - disease rateMurineMusMxi2Natural regenerationO elementO2 elementOrganOutcomeOxidative PhosphorylationOxidative Phosphorylation PathwayOxidative StressOxygenPathway interactionsPatientsPb elementPhenotypePhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPlatelet Transforming Growth FactorPredispositionProcessProductionProliferatingProtein DimerizationProtein PhosphorylationProteomeRegenerationRegulationResearchRoleSAPK2AScarsSclerodermaSignal TransductionSignal Transduction SystemsSignalingSkinSkin injurySourceStress-Activated Protein Kinase 2ASusceptibilityTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransphosphorylasesTransplantationValidationVariantVariationWarburg EffectWound RepairWound modelsXenograftXenograft ModelXenograft procedureXenotransplantationaerobic glycolysisantifibrotic agentantifibrotic medicationantifibrotic therapyantifibrotic treatmentbiobankbiological signal transductionbiomechanicalbiorepositorycareerclinical relevanceclinically relevantcomputer based predictioncutaneous injurydermatosclerosisdesigndesigningdevelopmentaldimerentire genomeepidermal injuryexperimentexperimental researchexperimental studyexperimentsfull genomegain of functionhealingheavy metal Pbheavy metal leadimprovedin vivoinjuriesinjuries to skininjury responseinjury to organsintracellular skeletonloss of functionmalignancymechanicmechanicalmechanical cuemechanical signalmechanosensingmechanotransductionmetabolic profilemigrationmitochondrialneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyorgan injuryp38p38 MAP Kinasep38 MAPK Genep38 Mitogen Activated Protein Kinasep38 Protein Kinasep38 SAPKp38-Alphap38Alphapathwaypredictive modelingpreventpreventingpsychosocialregenerateregenerativeresponseresponse to injuryskin healingsocial rolestemtissue repairtissue woundtranscriptomicstransplantvalidationswhole genomewoundwound healingwound healing modelswound recoverywound resolutionwoundingwoundsxeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
PROJECT SUMMARY
Dermal injury leads to fibrosis and scar formation, which can be a significant source of morbidity. Interestingly,
humans respond to identical skin injuries with different degrees of scar formation that range from low to high
scaring phenotypes. Understanding the mechanisms that drive heterogeneous scarring outcomes will allow us…
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