grant
Dietary factors, neuroinflammation, plasma neurodegenerative biomarkers and Alzheimer’s disease in diverse cohorts
Organization RUSH UNIVERSITY MEDICAL CENTERLocation CHICAGO, UNITED STATESPosted 15 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252-Phenyl-Benzopyrans2-Phenyl-ChromenesAD dementiaAD pathologyActive Follow-upAfrican AmericanAfro AmericanAfroamericanAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmentiaAmmon HornAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntioxidantsAstrocytesAstrocytusAstrogliaAstroproteinAutopsyBiological MarkersBlood PlasmaBrainBrain Nervous SystemBrain regionCellular StressCellular Stress ResponseClinicalClinical EvaluationClinical TestingCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionCommunitiesCornu AmmonisDataDementiaDietDietary FactorsDietary InterventionDifferences between sexesDiffers between sexesDisparitiesDisparityDisturbance in cognitionEncephalonEssential Fatty AcidsEvaluationFlavonoidsGFA-ProteinGFAPGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGlutathioneGoalsGrantHealth BenefitHealthy dietHippocampusHortega cellHumanImmuneImmunesImpaired cognitionInflammatoryInterventionKnowledgeLatinoLightLinkLipid PeroxidationLipidsMT-bound tauMeasuresMediatingMemoryMicrogliaMinorityModern ManNerve DegenerationNeuron DegenerationNutrientNutrition InterventionsNutritional InterventionsOutcomeOxidative StressPathogenesisPathologicPathologyPathway interactionsPersonsPhosphorylationPhotoradiationPlasmaPlasma SerumPolyunsaturated Fatty AcidsPopulationPopulation HeterogeneityPreventative strategyPrevention strategyPreventive strategyPrimary Senile Degenerative DementiaProtein PhosphorylationProteomicsPublic HealthRaceRacesReportingResearchResearch SpecimenReticuloendothelial System, Serum, PlasmaRiskRisk ReductionSamplingSex DifferencesSexual differencesSpecimenStructureTechniquesTestingTissue BanksTissue CollectionTissue repositoryUnderrepresented GroupsUnderrepresented Populationsactive followupaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationastrocytic gliabalanced dietbio-markersbiologic markerbiomarkerblood-based biomarkerblood-based markerbrain healthbrain tissuecell stressclinical diagnosisclinical testcognitive dysfunctioncognitive functioncognitive losscohortdesigndesigningdiet interventiondietarydietary approachdietsdifferences due to racedifferences in racediffers by racediffers in racediverse populationsfollow upfollow-upfollowed upfollowupgamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycinegitter cellgood dietheterogeneous populationhippocampalindividualized nutritioninnovateinnovationinnovativeinsightlipidomicsmesogliamicroglial cellmicrogliocytemicrotubule bound taumicrotubule-bound taunecropsyneural degenerationneural inflammationneurodegenerationneurodegenerativeneurofilamentneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationneuropathologicneuropathologicalneuropathologynoveloxidized lipidp-taup-τparticipant enrollmentpathwaypatient enrollmentperivascular glial cellpersonalized nutritionphospho-tauphospho-τphosphorylated taupopulation agingpopulation diversitypost-translational modification of taupostmortemposttranslational modification of tauprimary degenerative dementiaprotective effectrace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial originracially differentreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresearch clinical testingresearch studyresilienceresilientresponserisk-reducingsenile dementia of the Alzheimer typesexsex based differencessex-dependent differencessex-related differencessex-specific differencessystemic inflammationsystemic inflammatory responsetautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1traitunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peopleτ Proteinsτ phosphorylation
Description preview
Project Summary
N
resubmission in response to PAR-22-093. Prevention strategies, such as healthy sustainable
diets are critical and ase-related dementia (AD/ADRD) to have a population-wide
impact on reducing the risk of AD/ADRD for the growing aging population. Healthy diets are associated with slower
cognitive decline, reduced less AD pathology,…
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