grant
Diagnostic validity and safety of high-gamma language mapping with intracranial EEG
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Jun 2020Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAdultAdult HumanAmericanAnatomic SitesAnatomic structuresAnatomyAnticonvulsant AgentAnticonvulsant DrugsAnticonvulsantsAnticonvulsive AgentsAnticonvulsive DrugsAreaBrainBrain Nervous SystemChildChild YouthChildren (0-21)ClinicalCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexComprehensionDataDiagnosticDistantDisturbance in cognitionDrug TherapyE-stimEEGElectric StimulationElectrodesElectroencephalogramElectroencephalographyEncephalonEpilepsyEpileptic SeizuresEpilepticsEvoked PotentialsFreedomFundingGenerationsGoalsHumanImmediate MemoryImpaired cognitionImplanted ElectrodesIndividualIntractable EpilepsyLanguageLesionLibertyMapsMeasuresMethodologyMethodsModelingModern ManModernizationMonitorNamesNerve CellsNerve UnitNetwork-basedNeural CellNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurocyteNeuronsNeuropsychologiesNeuropsychologyOperative ProceduresOperative Surgical ProceduresOutcomePathway interactionsPatientsPharmacological TreatmentPharmacotherapyPhysiologic pulsePopulationPostoperativePostoperative PeriodProbabilityPropertyPulseRefractory epilepsySafetySeizure DisorderSeizuresSeveritiesShort-Term MemorySiteSpecificitySpeedStandardizationSurgicalSurgical InterventionsSurgical ManagementSurgical ProcedureSystemTask PerformancesTechniquesTestingVisualadulthoodclinical practiceclinical predictorscognitive dysfunctioncognitive losscohortdrug interventiondrug treatmentdrug-resistant epilepsyelectrostimulationepilepsiaepilepsy participantepilepsy patientepilepsy subjectepilepsy volunteerepileptic patientepileptic subjectepileptogenicimprovedindexingindividual patientkidslanguage outcomelanguage processingnamenamednamingneural controlneural regulationneuromodulationneuromodulatoryneuronalneuronal circuitneuronal circuitryneuropsychologicneuroregulationneurosurgerynext generationpathwaypatients with epilepsypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsrecruitresponseseizure drugseizure medicationspatial and temporalspatial temporalspatiotemporalstandard of caresurgeryverbalworking memoryyoungster
Description preview
PROJECT SUMMARY
The current clinical standard-of-care for neurosurgical interventions for drug-resistant epilepsy (DRE) involves the use
of intracranial electrodes for localization of individual cortical sites responsible for seizures and for sensorimotor and
language functions. This static localizationist approach has not kept pace with modern…
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