grant
Developmental pyrethroid exposure in the prairie vole as a model of environmental risk for autism
Organization UNIVERSITY OF TOLEDO HEALTH SCI CAMPUSLocation TOLEDO, UNITED STATESPosted 1 May 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20250-11 years oldASDAddressAdverse effectsAffectAssayAutismAutistic DisorderBehaviorBehavioralBioassayBiological AssayBiological MarkersBiological RhythmBlood SampleBlood specimenBrainBrain Nervous SystemCaringCausalityChildChild Development DisordersChild YouthChildren (0-21)Circadian DysregulationCircadian Rhythm PathwayCircadian Rhythm Sleep DisordersCitiesComplexCorpus StriatumCorpus striatum structureCricetinaeCross-Over DesignsCrossover DesignDataData SetDevelopmentDevelopmental DelayDevelopmental Delay DisordersDevelopmental DisabilitiesDiagnosisDiseaseDisorderDisturbed Nyctohemeral RhythmDoseDysfunctionEarly Infantile AutismEcological impactEmpathyEncephalonEnvironmentEnvironmental FactorEnvironmental ImpactEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEtiologyExhibitsExposure toFunctional disorderGene TranscriptionGeneral PopulationGeneral PublicGenesGenetic DiversityGenetic TranscriptionGenetic VariationGestationGoalsHamstersHamsters MammalsHourHumanHyperactivityIndigenousIndividualInfantile AutismKanner's SyndromeKinasesKnowledgeLaboratoriesLactationLearningLinkMeasuresMedicalMelatoninMiceMice MammalsMicrotusMidwestMidwest U.S.Midwest USMidwestern United StatesModelingModern ManMolecularMolecular TargetMothersMovementMultiomic DataMurineMusNatureNeurodevelopmental DisorderNeurological Development DisorderNeurosciencesOutcomePartner in relationshipPathway interactionsPatternPesticidesPhosphotransferase GenePhosphotransferasesPhysiopathologyPopulationPositionPositioning AttributePregnancyPregnant WomenPrevalencePreventionProteomicsPublishingRNA ExpressionRNA SeqRNA sequencingRNAseqResearchRetinol MetabolismRetinol Metabolism PathwayRiskRisk FactorsRodentRodentiaRodents MammalsRoleSamplingSleep-Wake Cycle DisordersSleep-Wake Schedule DisordersSocial BehaviorSocial NetworkSpecific Child Development DisordersStriate BodyStriatumTechnologyTestingTherapeutic InterventionTimeTranscriptionTransphosphorylasesTryptophan MetabolismTryptophan Metabolism PathwayVoleWild Animalsautism spectral disorderautism spectrum disorderautistic individualsautistic peopleautistic spectrum disorderbehavior outcomebehavior phenotypebehavior predictionbehavioral outcomebehavioral phenotypingbehavioral predictionbio-markersbiologic markerbiomarkerbody movementcausationcell typecircadiancircadian abnormalitycircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentco-morbidco-morbiditycohortcomorbiditydecamethrindeltamethrindevelopmentaldisease causationenvironmental riskepidemiologic investigationepidemiology studyexpectant motherexpectant womenexpecting motherexpecting womenfield mouseglobal gene expressionglobal transcription profileindividuals on the autism spectrumindividuals on the spectrumindividuals who are pregnantindividuals with ASDindividuals with autismindividuals with autism spectrum disorderintervention therapykidslactatinglactationalmatemulti-modalitymultimodalitymultiomicsmultiple omic datamultiple omicsneurodevelopmental diseaseoffspringpanomicspathophysiologypathwaypeople on the autism spectrumpeople who are pregnantpeople with ASDpeople with autismpeople with autism spectrum disorderpesticide exposureprairie volepregnant femalespregnant motherspregnant peoplepregnant populationspyrethroidrepetitive behaviorresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocialsocial rolesociobehaviorsociobehavioralstriatalsuccesssuprachiasmatic nucleustargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthose who are pregnanttranscriptometranscriptome sequencingtranscriptomic sequencingvocalizationwomen who are pregnantyoungster
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Project Summary
The prevalence of autism and other neurodevelopmental disorders (NDDs) is at an all-time high, with 17% of
children diagnosed with a developmental disability and 1 in 44 diagnosed with autism. Many of these disorders
have few or no established biomarkers, few or no medical treatments, and can only be diagnosed behaviorally,…
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