grant
Developmental Pathophysiology of Adverse Patterns of Substance Use in Adolescents with Anxiety
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Jul 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202612 year old12 years of age12-20 years oldAcuteAdolescenceAdolescentAdolescent YouthAeroseb-HCAffectiveAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnxietyBehavioralBiological MarkersBrainBrain Nervous SystemCausalityCetacortCharacteristicsClinicCognitiveCort-DomeCortefCortenemaCortisolCortisprayCortrilDataData CollectionDermacortDetectionDevelopmentDiagnosisDifferences between sexesDiffers between sexesDiseaseDisorderDysfunctionEldecortEmotionalEncephalonEquipment and supply inventoriesEtiologyExhibitsExposure toFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderGoalsHeterogeneityHydrocortisoneHydrocortoneHytoneImpulsivityInformal Social ControlInterventionInventoryLinkLong-term prospective studiesLongitudinal StudiesLongitudinal SurveysMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingMonitorNMR ImagingNMR TomographyNerve CellsNerve UnitNeural CellNeural DevelopmentNeural PathwaysNeurobiologyNeurocyteNeuronsNuclear Magnetic Resonance ImagingNutracortOutcomePathway interactionsPatternPersonalized medical approachPhysiologicPhysiologicalPhysiologyPhysiopathologyPredicting RiskProcessProctocortRegulationReportingRestRiskRoleSalivarySamplingSelf RegulationSeveritiesSex DifferencesSexual differencesSocial Support SystemStressSubstance Use DisorderSupport SystemSurvey InstrumentSurveysSymptomsSystemTask PerformancesTestingTimeWorkYouthYouth 10-21Zeugmatographyacute stressadolescence (12-20)adolescent substance useage 12age 12 yearsalleviate symptomameliorating symptomamygdaloid nuclear complexanxiety symptomsanxious symptombehavior outcomebehavioral outcomebio-markersbiologic markerbiological adaptation to stressbiomarkerbiomarker identificationcausationclinical diagnosiscognitive controldecrease symptomdesigndesigningdevelopmentaldisease causationefficacious interventioneligible participantexternalizing behaviorfMRIfewer symptomsforecasting riskgraph theoryheart rate variabilityhigh riskhigh-risk adolescentsidentification of biomarkersidentification of new biomarkersimprovedindividualized approachinformation processingintervention designjuvenilejuvenile humanlong-term studylongitudinal courselongitudinal outcome studieslongitudinal research studylongitudinal, prospective studymarker identificationmedial temporal areamedial temporal lobemesial temporal areamesial temporal lobemultimodal modelingneuralneural imagingneural networkneuro-imagingneurobiologicalneurodevelopmentneuroimagingneurological imagingneuronalpathophysiologypathwaypersonalized approachprecision approachpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpredictive riskpredicts riskprogramsprospectivereaction; crisisrecruitreduce symptomsrelieves symptomsresponserisk predictionrisk predictionssecondary analysissex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolesocial stresssocially stressedstress reactivitystress responsestress; reactionstressorsubstance usesubstance use among adolescentssubstance use among youthsubstance use and disordersubstance usingsubstance using adolescentssupport networksymptom alleviationsymptom reductionsymptom relieftailored approachtherapy designtreatment designtwelve year oldtwelve years of ageyouth ageyouth substance use
Description preview
The proposed 5-year R01 study will examine maturational pathways of biomarkers (neural connectivity and
stress physiology) to adverse patterns of substance use (APSU) in adolescents with anxiety symptoms to
improve precision-based, targeted intervention. Anxiety remains one of the most commonly diagnosed clinical
symptom domains in adolescence and…
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