grant
Developmental Origins of Aggressive and Impulsive Behavior
Organization NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INCLocation NEW YORK, UNITED STATESPosted 1 Mar 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202512-20 years old21+ years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acid5-HT5-HT(2C) Receptor5-HT2C Receptor5-Hydroxytryptamine5-Hydroxytryptamine Type 2C Receptors5HT5HT transporter5HTT proteinAdolescenceAdultAdult HumanAggressionAggressive behaviorAminalonAminaloneAppetiteBehaviorBehavioralBrainBrain Nervous SystemCell Communication and SignalingCell SignalingClassificationClinicalClinical ResearchClinical StudyCoupledD(2) Dopamine Receptor GeneD2 receptorD2DRD2DR GeneD2RD2R GeneDAT dopamine transporterDRD2DRD2 ReceptorDRD2 geneDataDesire for foodDevelopmentDiagnosisDifferences between sexesDiffers between sexesDopamineDopamine D2 ReceptorDopamine Receptor D2 GeneDorsalDysfunctionEncephalonEnteramineEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEstrusFemaleFunctional disorderGABAGeneralized GrowthGeneticGrowthHippophaineHumanHydroxytyramineHyperactivityHypothalamic structureHypothalamusImpulsive BehaviorImpulsivityIntracellular Communication and SignalingInvestigationKnowledgeLateralLinkMapsMediatingMeditationMiceMice MammalsModelingModern ManMonitorMurineMusNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuronsNeurotransmittersNucleus AccumbensPathway interactionsPhenotypePhysiopathologyPlayPreventative strategyPrevention strategyPreventive strategyPsychiatryPublic HealthResearchResolutionRewardsRisk FactorsRoleSelf AdministeredSelf AdministrationSerotoninSerotonin 2C ReceptorSerotonin Receptor 5-HT2CSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSiteSocial isolationStimulantSystematicsTestingTimeTissue GrowthVentral Tegmental AreaViolenceadolescence (12-20)adulthoodbiological signal transductioncomparing females and malescomparing women and mendevelopmentaldopamine systemdopamine transporterepidemiologic investigationepidemiology studyestrousexperimentexperimental researchexperimental studyexperimentsfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfightinggamma-Aminobutyric Acidhypothalamicimprovedinsightmalemonoaminemouse modelmurine modelneural circuitneural circuitryneurocircuitryneuronalneuropsychiatric diseaseneuropsychiatric disordernovelontogenyoptogeneticspathophysiologypathwayperiadolescentpsychostimulantreceptor expressionresolutionsresponsesensorserotonin transportersexsex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsocial rolesodium-dependent serotonin transportersynaptic circuitsynaptic circuitrytooltranslational modeltreatment strategyventral tegmentumviolentviolent behaviorwomen compared to menwomen compared with menwomen versus menwomen vs. menγ-Aminobutyric Acid♀♂
Description preview
Project Summary. Septal-hypothalamic neuronal activity centrally mediates aggressive behavior, while the
monoamine neurotransmitters dopamine and serotonin play strong and mostly opposing modulatory roles.
However, related circuit mechanisms and ontogeny are largely unknown. Making progress towards circuit
mechanism, we found in mice that dopamine…
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