grant
Development of synthetic heparin to protect liver graft from ischemia reperfusion injury during transplantation
Organization GLYCO DISCOVERIES, INCLocation RALEIGH, UNITED STATESPosted 1 Jul 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Activated Blood Coagulation Factor XActivated Factor XActive OxygenAcuteAddressAffectAllograftingAmphoterinAmphoterin GeneAsystoleAutoprothrombin CAwardBiliaryBiologicalBlood PlateletsCancer ModelCancerModelCarbohydratesCardiac ArrestCardiac DeathCell CoatCell surfaceChromosomal Protein, Nonhistone, HMG1Chromosomal Protein, Nonhistone, HMG1 GeneClottingCoagulantsCoagulationCoagulation Factor XaCoagulation ProcessCollaborationsCommon Rat StrainsComplicationCryofixationCryopreservationDevelopmentDevelopment PlansDysfunctionEndothelial CellsFM1 Gene ProductFactor XaFamily suidaeFlushingFunctional disorderFundingGlycocalyxGoalsGraft SurvivalGrafting ProcedureHMG-1HMG-1 GeneHMG-1 ProteinHMG1HMG1 GeneHMG3HMG3 GeneHMGB1HMGB1 ProteinHMGB1 geneHeart ArrestHemostasisHemostatic functionHeparinHeparin-Binding Protein p30Heparinic AcidHepatic NeoplasmsHepatic TransplantationHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatomaHigh Mobility Group Box Protein 1High Mobility Group Protein 1High Mobility Group Protein 1 GeneHigh-Mobility Group (Nonhistone Chromosomal) Protein 1High-Mobility Group (Nonhistone Chromosomal) Protein 1 GeneHigh-Mobility Group Box 1High-Mobility Group Box 1 GeneHumanInflammationInflammatoryInflammatory ResponseInjury to LiverIschemiaIschemia-Reperfusion InjuryLifeLiverLiver Cells CarcinomaLiver GraftingLiver TransplantLiver neoplasmsMalignant CellMarketingMarrow plateletMedicalMethodsMitochondriaModelingModern ManMolecularMonitorNO2National Institutes of HealthNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic InfiltrateNitrogen DioxideNitrogen PeroxideNonhistone Chromosomal Protein HGM1Nonhistone Chromosomal Protein HGM1 GeneNorth CarolinaOligosaccharidesOrganOrgan Preservation SolutionsOrgan SizeOrgan TransplantationOrgan TransplantsOutcomeOxygen RadicalsPatientsPatternPerfusionPhasePhysiopathologyPigsPlateletsPredispositionPrimary carcinoma of the liver cellsPro-OxidantsProceduresProcessRatRats MammalsRattusReactive Oxygen SpeciesReagentRecoveryRecurrent NeoplasmRecurrent tumorReperfusion DamageReperfusion InjuryReperfusion TherapyResearchRetrospective StudiesRodentRodentiaRodents MammalsSBP-1SBP-1 GeneSTTRSamplingSeveritiesSmall Business Technology Transfer ResearchSterilityStructureSuidaeSulfoglucuronyl Carbohydrate Binding ProteinSulfoglucuronyl Carbohydrate Binding Protein GeneSusceptibilitySwineTherapeuticThrombocytesThrombokinaseThrombusTimeTissue Preservation SolutionsTranslatingTransplantationUnited States National Institutes of HealthUniversitiesWorkadverse consequenceadverse outcomebiologiccancer cellclinical relevanceclinically relevantcold preservationcold storagedeceased donordeceased organ donorsdevelopmentaleffective therapyeffective treatmentend stage liver diseaseend stage liver failureexperienceexperimentexperimental researchexperimental studyexperimentsfirst in manfirst-in-humangraft functionhepatic body systemhepatic damagehepatic injuryhepatic ischemiahepatic neoplasiahepatic neoplasmhepatic organ systemhepatic tumorhuman studyimprovedinjury burdenliver cancer patientliver carcinomaliver damageliver functionliver injuryliver ischemialiver preservationliver transplantationliver tumormeetingmeetingsmitochondrialneoplasm recurrenceorgan allograftorgan graftorgan xenograftpathophysiologyporcinepost-transplantpost-transplantationposthumous donorsposthumous organ donorposttransplantposttransplantationpre-clinical studypreclinical studypreservationpreventpreventingprothrombasereperfusionresponseretransplantationsterilesuccesssuidtransplanttransplant modeltumor growth
Description preview
Project Summary/Abstract
This STTR phase II application is to seek continuation support to develop a carbohydrate-based
reagent, dekaparin, to protect from liver damage during the organ recovery and preservation
process. Liver transplant is an effective treatment option for hepatocellular carcinoma and end
stage liver disease patients. However,…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click