grant
Development of small-molecule autophagy modulators
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAffectAgingAssayAutophagocytosisAutophagosomeAutoregulationBindingBioassayBiochemistryBiologicalBiological AssayBiological ChemistryBiological FunctionBiological ProcessBiologyCancer TreatmentCancersCatabolic ProcessCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular biologyCephalinsChaperoneChemical FractionationChemicalsCollectionComplexComplex MixturesDevelopmentDiseaseDisorderEndosomesEnergy TransferEthanolamine PhosphoglyceridesEthanolamineglycerophospholipidsEukaryotaEukaryoteEvaluationFRACNFluorescence PolarizationFractionationFractionation RadiotherapyGoalsHigh Throughput AssayHomeostasisHuman BiologyInterdisciplinary ResearchInterdisciplinary StudyInvestigationKinasesLaboratoriesLamin ALamin Type ALipidsLysosomesLytotoxicityMaintenanceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryManuscriptsMedicinal ChemistryMembraneMetabolicMetabolic Protein DegradationMicrosomesModelingMolecular ChaperonesMolecular InteractionMolecular TargetMultidisciplinary CollaborationMultidisciplinary ResearchNatural ProductsNerve DegenerationNeuron DegenerationNutrientO-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)-ethanolamineOrganic ChemistryOvary CancerPathway interactionsPatientsPharmaceutic ChemistryPharmaceutical ChemistryPhenotypePhosphatidylethanolaminePhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPreparationProcessPropertyProtein TurnoverProteinsReceptosomesRecurrenceRecurrentRecyclingRegulatory Protein DegradationResistanceRoleSolubilityStructure-Activity RelationshipSubcellular ProcessTherapeuticTherapeutic InterventionTransphosphorylasesWorkaberrant folded proteinaberrant folded proteinsaberrant protein foldingabnormal folded proteinabnormal folded proteinsabnormal protein foldinganaloganti-cancer therapyautophagybiologicbrain healthcancer progressioncancer therapycancer typecancer-directed therapycell biologycell stresschemical structure functionclinical applicabilityclinical applicationcompound optimizationcytotoxicitydevelopmentaldrug discoveryefficacy studyformulation optimizationfunctional grouphealthy aginghealthy human aginghigh throughput screeninghuman diseaseimprovedin vivoinhibition of autophagyinhibitorinterestintervention therapymalignancymembrane structuremisfolded proteinmisfolded proteinsmolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentmutantnaturally occurring productneoplasm progressionneoplasm/cancerneoplastic progressionneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationneuroprotectionneuroprotectivenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachovarian cancerpathologic protein foldingpathwaypreparationspreventpreventingprotein degradationprotein functionprotein homeostasisprotein misfoldingprotein protein interactionproteostasisproteotoxic proteinproteotoxinrare genetic diseaserare genetic disorderrecruitresistantscaffoldscaffoldingscreeningscreeningssmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolestructure function relationshiptherapeutic agent developmenttherapeutic developmenttraffickingtumor progression
Description preview
Autophagy has been implicated in numerous diseases, including many cancers, but the difficulty of selectively targeting this pathway has presented major challenges for therapeutic development. My laboratory aims to discover novel autophagy modulators to better understand the fundamental roles of this pathway in human biology and disease.…
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