grant
Development of Potent and non-toxic rexinoids to prevent non-melanoma skin cancer
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 7 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202613 cis retinoate13-cRA13-cis-Retinoic Acid13-cis-Vitamin A Acid3-methyl TTNEB9-cRA9-cis-Retinoic Acid9-cis-Retinoic Acid ReceptorATRAAcidityAdverse effectsAgonistAmerican Cancer SocietyAnimalsApoptosisApoptosis PathwayBasal Cell EpitheliomaBasal cell carcinomaBasilomaBexaroteneBindingBioavailabilityBiological AvailabilityBiological MarkersBlood SerumCalorimetryCancer BiologyCancer ModelCancerModelCancersCarbonCarboxylic AcidsCarcinoma CellCause of DeathCell RespirationCellular RespirationChemopreventiveChemopreventive AgentChronicClinicalComplexCutaneous Lymphoproliferative DisorderDataDevelopmentDiseaseDisorderDoseDrug KineticsDrugsEconomic BurdenEmotionalEpidermoid CarcinomaEvaluationF elementFDA approvedFluorineGene TranscriptionGenetic TranscriptionGrantGroup 17 ElementsH elementHalf-LifeHalogensHomoHumanHydrogenHyperlipemiaHyperlipidemiaImmuneImmunesImmunityIn VitroIndividualInflammationInflammatoryInvestigationInvestigatorsIsotretinoinIsotretinoinumKeratinocyte carcinomaLaboratoriesLigand BindingLipidsLiver X ReceptorLymphoproliferative Disorder of the SkinMalignant Epithelial CellMalignant NeoplasmsMalignant TumorMeasuresMedicationMetabolicModelingModern ManModificationMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryNitrogenNon-Melanoma Skin CancerNuclear ReceptorsOralParentsPeptidesPharmaceutical PreparationsPharmacokineticsPhase I StudyPhysiologic AvailabilityPlanocellular CarcinomaPlayPolyenesPopulationPrevent skin cancerPreventative strategyPreventionPrevention strategyPreventivePreventive strategyProgrammed Cell DeathProliferatingPropertyProteinsRNA ExpressionRXRRXR ProteinReceptor ProteinResearch PersonnelResearchersRetinoic AcidRetinoic Acid AgentRetinoic Acid ReceptorRetinoic Acid Receptor RXRRetinoic Acid and DerivativesRetinoicacid-13-cisRetinoicacid-9-cisRetinoid X ReceptorsRetinoidsRodent UlcerRoentgen RaysRoleSafetySerumSingle Crystal DiffractionSkinSkin CarcinogenesisSkin CarcinomaSolidSquamous CarcinomaSquamous Cell EpitheliomaSquamous cell carcinomaStructureSurfaceTargretinTetralonesTitrationsToxic effectToxicitiesTrans Vitamin A AcidTranscriptionTranslatingTranslationsTretinoinTretinoinumUVB inducedVitamin A AcidX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray Crystallographyaerobic metabolismaerobic respirationalitretinoinall-trans-Retinoic Acidall-trans-Vitamin A acidanaloganti-carcinogenicbasal cell carcinoma of skinbio-markersbiologic markerbiomarkerbiophysical analysisbiophysical studiescancer chemopreventioncancer diagnosiscancer typechemoprevention agentcis-Retinoic Acidclinical candidateclinical developmentcombatconformationconformationalconformational stateconformationallyconformationscutaneous carcinogenesiscutaneous lesionsdermal lesiondesigndesigningdevelopmentaldrug/agentexperimentexperimental researchexperimental studyexperimentshigh riskhuman modelimprovedinnovateinnovationinnovativelipophilicitymalignancymembermetabolic profilemodel of humanmouse modelmurine modelneoplasm/cancernon-compliancenon-compliantnoncompliancenoncompliantnonmelanoma skin cancernovelorgan transplant patientorgan transplant recipientoxidative metabolismparentpharmacologicphase 1 studypre-clinicalpre-clinical developmentpre-clinical evaluationpreclinicalpreclinical developmentpreclinical evaluationpreventpreventingprospectivereceptorrecruitside effectskin cancer preventionskin lesionsmall moleculesocial roletime intervaltissue biomarkerstrans-Retinoic Acidtranslationultraviolet B inducedultraviolet b radiation inducedultraviolet light b inducedwater solubility
Description preview
Abstract:
Non-melanoma skin cancer (NMSC), which include basal cell carcinoma (BCC) and squamous cell carcinoma
(SCC) is one of the most common types of cancers in the US. Due to compromised immunity, solid organ
transplant recipients (SOTRs) are at a much higher risk for NMSC and it often becomes the cause of death in
SOTRs. Prevention of NMSC is…
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