grant
Development of photocaged DREADD agonists for high-efficiency, target-specific optical silencing of synaptic transmission
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20263'5'-cyclic ester of AMPActinic RaysAddressAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AgonistAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimal ExperimentsAnimalsArtifactsAssayAxonBehaviorBehavior assessmentBehavior monitoringBehavioralBenchmarkingBest Practice AnalysisBioassayBiological AssayBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain Nervous SystemBrain regionCannulasCell BodyCell Communication and SignalingCell Culture TechniquesCell NucleusCell SignalingCellsCommunitiesComplexConnector NeuronConsultationsCornu AmmonisCorpus StriatumCorpus striatum structureCustomized DrugsCyclic AMPDA NeuronDREADDsDarknessDependenceDesigner DrugsDevelopmentDiffusionDopamine neuronDorsalDoseDrug KineticsDrug PrecursorsE-stimElectric StimulationElectrophysiologyElectrophysiology (science)EncephalonEndowmentEvaluationFiberFluorescenceFluorescent ProbesGeneticHemato-Encephalic BarrierHippocampusIlluminationImageImplantIn VitroInfusionInfusion proceduresIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingInvestigatorsLigandsLightLightingLiquid substanceLocus CoeruleusMeasurementMediatingMethodsMiceMice MammalsMorphologic artifactsMurineMusNasalNasal Passages NoseNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural TransmissionNeurocyteNeuronal TransmissionNeuronsNeurophysiology - biologic functionNeurophysiology / ElectrophysiologyNeurosciencesNoseNucleusNucleus AccumbensNucleus Pigmentosus PontisOpiate ReceptorsOpiatesOpioidOpioid ReceptorOpticsOutputPenetrancePerformancePharmacokineticsPhotometryPhotoradiationPhysiologyPlayPopulationPositionPositioning AttributePro-DrugsProdrugsReagentResearch PersonnelResearchersResolutionRespiratory System, Nose, Nasal PassagesRewardsRoleSignal TransductionSignal Transduction SystemsSignalingSiteSliceSourceStimulusStriate BodyStriatumSynapsesSynapticSynaptic TransmissionTechniquesToxic effectToxicitiesUV lightUV radiationUV raysUltraviolet RaysValidationVentral Tegmental AreaViralWorkadenosine 3'5' monophosphateanimal experimentantinociceptionantinociceptiveawakeaxon signalingaxon-glial signalingaxonal signalingbehavior responsebehavioral assessmentbehavioral monitoringbehavioral responsebenchmarkbiological signal transductionbloodbrain barrierblue nucleuscAMPcell culturecell culturescell typecholinergicconsultationdesigndesigner receptors exclusively activated by designer drugsdesigningdevelopmentaldiffuseddiffusesdiffusingdiffusionsdopaminergic neuronelectrophysiologicalelectrostimulationexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentsfluidglia signalingglial signalinghippocampalimagingin vivoinfusionsinterestlight intensityliquidlocus ceruleus structureminimally invasivenerve signalingneuralneural controlneural functionneural networkneural regulationneural signalingneural stimulationneurochemicalneurochemistryneuromodulationneuromodulatoryneuronalneuronal signalingneuroregulationneurotransmissionopticaloptical fiberoptogeneticspharmacologicphotoactivationpresynapticresolutionsresponsescreeningscreeningssocial rolespatial and temporalspatial temporalspatiotemporalstriatalsynapsesynapse inhibitionsynaptic inhibitiontoolultra violetultra violet lightultra violet radiationultra violet raysultravioletultraviolet lightultraviolet radiationuptakevalidationsventral tegmentum
Description preview
Genetically-encoded tools that provide researchers with a means to control neural activity in genetically-defined cell types are widely used to establish causal relationships between neural activity and behavior. Current tools for silencing synaptic output in a way that is restricted to anatomically-defined target nuclei in the brain suffer from…
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