grant
Development of pan-betacoronavirus vaccines
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 3 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAddressAffinityAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody ResponseAntigenic DeterminantsAntigensApplications GrantsB blood cellsB cellB cell receptorB cellsB-Cell ActivationB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBetaCoV vaccineBindingBinding DeterminantsCOVID-19COVID-19 infectionCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 virusCV-19Clinical EvaluationClinical TestingCoV S proteinCoV emergenceCoV glycoprotein SCoV pandemicCoV spike glycoproteinCoV spike proteinCoV-2CoV2CoronaviridaeCoronaviridae InfectionsCoronavirusCoronavirus InfectionsCoronavirus Infectious Disease 2019Coronavirus glycoprotein SCoronavirus spike proteinDevelopmentDirected Molecular EvolutionElementsEngineeringEpitopesFutureGametesGeneticGerm CellsGerm LinesGerm-Line CellsGoalsGrant ProposalsHCoVHealthHumanImmune responseIn VitroInterventionIntervention StrategiesKnowledgeMERS corona virusMERS coronavirusMERS virusMERS-CoVMethodsMiddle East Respiratory Syndrome Corona VirusMiddle East Respiratory Syndrome CoronavirusMiddle East Respiratory Syndrome VirusMiddle East Respiratory Syndrome-CoVMiddle East Respiratory VirusMiddle East Respiratory coronavirusMiddle Eastern Respiratory Syndrome Corona virusMiddle Eastern Respiratory Syndrome CoronavirusMiddle Eastern Respiratory Syndrome VirusMiddle Eastern Respiratory Syndrome-CoVModelingModern ManMolecularMolecular InteractionOrthocoronavirinaePeptidesPreventative vaccinePreventive vaccinePropertyProphylactic vaccineProtein EngineeringProteinsReproducibilityReproductive CellsSARS VirusSARS corona virusSARS corona virus 2SARS coronavirusSARS-Associated CoronavirusSARS-CO-V2SARS-COVID-2SARS-CoVSARS-CoV-1SARS-CoV-2SARS-CoV-2 infectionSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-CoV2 infectionSARS-Related CoronavirusSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SarbecovirusSevere Acute Respiratory CoronavirusSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2Sex CellSiteTestingTranslatingTransmissionVaccinationVaccine DesignVaccinesVirusWorkWuhan coronavirusZoonosesZoonoticZoonotic Infectionactivated B cellsantibody engineeringbeta CoVbeta coronavirusbeta coronavirus vaccinebetaCoVbetacoronavirusbetacoronavirus vaccineclinical testcorona viruscorona virus emergencecoronavirus S proteincoronavirus disease 2019coronavirus disease 2019 infectioncoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease-19coronavirus disease-19 viruscoronavirus emergencecoronavirus infectious disease-19coronavirus of pandemic concerncoronavirus of pandemic potentialcoronavirus pandemiccoronavirus spike glycoproteincoronavirus vaccinecoronavirus with pandemic potentialcurrent pandemicdesigndesigningdevelop a vaccinedevelop therapydevelop vaccinesdevelopment of a vaccinedevelopmentaldirected evolutionemergent CoVemergent corona virusemergent coronavirusemerging CoVemerging corona virusemerging coronavirusevaluate vaccinesfuture outbreakgenetic protein engineeringhCoV19host responsehuman CoVhuman corona virushuman coronavirusimmune system responseimmunization strategyimmunogenimmunoresponsein vivoinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2initial cellintervention developmentmodel of animalnCoVnCoV2nano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodynew CoVnew corona virusnew coronavirusnew vaccinesnext generation vaccinesnext outbreaknovelnovel CoVnovel corona virusnovel coronavirusnovel vaccinesoutbreak containmentoutbreak controloutbreak in the futureoutbreak mitigationpan CoV vaccinepan coronavirus vaccinepanCoV vaccinepanbetaCoV vaccinepancoronavirus vaccinepandemicpandemic concernpandemic coronaviruspandemic diseasepandemic disease preparednesspandemic planningpandemic potentialpandemic preparednesspandemic readinesspandemic riskpandemic threatpandemic threat coronaviruspre-clinicalpreclinicalpresent pandemicprotective efficacyprotein designprototyperational designresearch clinical testingrespiratorysevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssevere acute respiratory syndrome-CoVsexual cellstemtherapy developmenttooltransmission processtreatment developmentuniversal CoV vaccineuniversal coronavirus vaccinevaccination protocolvaccination strategyvaccination studyvaccination trialvaccine against coronavirusvaccine antibodiesvaccine candidatevaccine candidate against coronavirusvaccine developmentvaccine efficacyvaccine evaluationvaccine induced antibodiesvaccine platformvaccine protocolvaccine screeningvaccine strategyvaccine studyvaccine testingvaccine trialvaccine-induced antibodiesvaccines against betacoronavirusesvaccines targeting the betacoronavirusvariants of concernwelfareβ CoVβ coronavirusβ coronavirus vaccineβCoV
Description preview
PROJECT SUMMARY/ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus identified at the end of
2019, has led to the current global pandemic. The SARS-CoV-2 virus belongs to the subgenus sarbecovirus of
the genus betacoronavirus, the genus from which two SARS-CoV-2 closely related viruses (SARS-CoV-1 and…
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