grant
Development of novel AAV vaccine strategy in a pre-clinical model of oral melanoma.
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 8 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025(TNF)-α5,6-dihydroxyindole-2-carboxylic acid oxidaseAAV vectorAAV-based vectorAchievementAchievement AttainmentActive ImmunizationActive vaccinationAddressAdeno-Associated VirusesAdjuvantAgeAnimal ModelAnimal Models and Related StudiesAntigen Presentation PathwayAntigen Processing and PresentationAntigen TargetingAntigen-Presenting CellsAntigensAntineoplastic VaccineAssayBasic ResearchBasic ScienceBioassayBiological AssayBiomedical EngineeringCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCMVCachectinCancer TreatmentCancer VaccinesCancersCanine SpeciesCanis familiarisCapsidCell BodyCell Communication and SignalingCell SignalingCellsChemotactic CytokinesClass I AntigensClass I Major Histocompatibility AntigensClone CellsComplexComplex Class 1CresolaseCross PresentationCutaneous MelanomaCytomegalovirusDHI2C oxidaseDHICA oxidaseDNA ReplicationDNA SynthesisDNA biosynthesisDNA cassetteDataDendritic CellsDependoparvovirusDependovirusDevelopmentDisease ProgressionDissectionDisseminated Malignant NeoplasmDogsDogs MammalsDopa OxidaseDopachrome isomeraseDoseDose LimitingELISAEngineeringEnvironmental ExposureEnzyme-Linked Immunosorbent AssayEquilibriumExpression SignatureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional impairmentGP100Gene Expression ProfileGene Therapy VectorsGene Transduction AgentGene Transduction VectorsGenesGeneticGenetic MarkersGenotoxinsHCMVHeterogeneityHistocompatibility Antigens Class IHomologous Chemotactic CytokinesHumanIFN-GammaIFN-gIFN-γIFNGIFNγImmuneImmune InterferonImmune Modulation TherapyImmune RegulatorsImmune mediated therapyImmune responseImmune systemImmunesImmunologic StimulationImmunological StimulationImmunologically Directed TherapyImmunomodulatorsImmunostimulationImmunotherapyIndividualInflammatory ResponseInjectionsIntercrinesInterferon GammaInterferon Type IIIntracellular Communication and SignalingIntramuscularKineticsL-SerineL-ThreonineL-ValineLYT3Lip and Oral Cavity NeoplasmLip and Oral Cavity TumourLocal TherapyLocalized TherapyME20MHC Class I MoleculeMHC Class I ProteinMHC class I antigenMacrophage-Derived TNFMajor Histocompatibility Complex Class 1Malignant Cutaneous MelanomaMalignant MelanomaMalignant Melanoma of SkinMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMelanocyte Protein 17MelanomaMelanoma SkinMelanoma TumorMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsModelingModern ManModificationMolecularMonocyte-Derived TNFMonophenol MonooxygenaseMouse Homolog of SILVERMouth NeoplasmsMouth TumorMucosaMucosal TissueMucous MembraneMutagensNeoplasm MetastasisNeoplasm VaccinesNuclear TranslocationOncologistOperative ProceduresOperative Surgical ProceduresOralOral Cavity NeoplasmOral Cavity TumorOral MelanomaOral NeoplasmsOral TumorPMEL genePMEL proteinPMEL17PatientsPersonsPhenol OxidasePhenoloxidasePopulationPre-Clinical ModelPreclinical ModelsPremelanosomal ProteinPrevalenceProductionProliferatingPropertyPublic HealthRecurrent NeoplasmRecurrent tumorReportingResearchResistanceSILV geneSILV proteinSIS cytokinesSafetySalivary Gland VirusesSecondary NeoplasmSecondary TumorSerineSerotypingSignal TransductionSignal Transduction SystemsSignalingSiteSurfaceSurgicalSurgical InterventionsSurgical ProcedureT-Cell ProliferationT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTRP-2TestingTherapeuticThreonineToxic effectToxicitiesTreatment FailureTreatment outcomeTumor AntigensTumor ImmunityTumor Necrosis FactorTumor Necrosis Factor-alphaTumor VaccinesTumor growth in melanomaTumor-Associated AntigenTyrosinaseTyrosinase related protein-1Tyrosinase-Related Protein-2VAC-TXVaccinationVaccine TherapyVaccinesValineVeiled CellsViralViral GenomeVirusaccessory celladaptive immune responseadeno associated virus groupadeno-associated viral vectoradeno-associated virus vectoragesanti-cancer immunotherapyanti-cancer therapyanti-tumor immunityanti-tumor vaccineanticancer immunotherapyantigen processingantitumor immunitybalancebalance functionbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductioncancer antigenscancer immunitycancer immunotherapycancer metastasiscancer therapycancer-directed therapycaninechemoattractant cytokinechemokinechemotherapyclinical relevanceclinically relevantcombinatorialcompanion dogcytokinecytomegalovirus groupdermal melanomadesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldihydroxyindole-carboxylic acid oxidasedomestic dogdopachrome conversion factordopachrome oxidoreductasedopachrome tautomerasedosageenhancer cassetteenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsexpression cassetteflow cytophotometrygene biomarkergene cassettegene expression biomarkergene expression patterngene expression signaturegene markergene signature biomarkergenetic biomarkergenetic cassettegenotoxic agenthost responseimmune modulatorsimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmune-modulation treatmentimmuno therapyimmunogenimmunogenicimmunogenicityimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory moleculesimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatorimmunoregulatory moleculesimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimmunotherapy for cancerimmunotherapy of cancerimprovedin vivointegration cassettelFN-Gammamalignancymodel of animalmonophenol oxidasemucosal melanomamultiplex assayneoplasm recurrenceneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynew vaccinesnext generationnext generation vaccinesnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnovel vaccinesoral neoplasiapre-clinicalpre-clinical studypreclinicalpreclinical studyprogramspromoterpromoter cassettepromotorreporter cassetteresistance cassetteresistantresponseselectable cassetteselection cassetteside effectstop cassettesurgerytherapeutic agent developmenttherapeutic developmenttherapeutic immunomodulationtherapeutic immunoregulationtherapeutic vaccinationtherapy failurethymus derived lymphocytetraffickingtranscription cassettetranscriptional cassettetranscriptional profiletranscriptional signaturetransduction efficiencytransgene cassettetumortumor cell metastasistumor diagnosistumor-specific antigentyrosinase-related TRP-1 proteintyrosinase-related TRP1 proteintyrosinase-related proteinvaccine developmentvaccine for cancervaccine platformvaccine strategyvectorviral DNAvirus DNAvirus genome
Description preview
Project Summary/Abstract
Vaccination is a potent regulator of the immune system and much research is being conducted to understand
how antigen-specific stimulation can be used to induce and redirect anti-tumor immunity. Our team develops a
cancer immunotherapy program using novel AAV vectors to deliver antigens both directly and by cross-…
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