grant

Development of Natural Product Leads as Anticancer Therapeutics

Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AcademiaAchievementAchievement AttainmentAddressAnimal ModelAnimal Models and Related StudiesAnimalsAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsCNS TumorCNS neoplasmCancer Cell GrowthCancer DrugCancersCentral Nervous System NeoplasmsCentral Nervous System TumorsDevelopmentGrawitz TumorHeterograftHeterologous TransplantationHypernephroid CarcinomaHypernephromaMalignant NeoplasmsMalignant TumorMesotheliomaMiceMice MammalsMurineMusNSCLCNSCLC - Non-Small Cell Lung CancerNatural CompoundNatural ProductsNeoplastic Disease Chemotherapeutic AgentsNephroid CarcinomaNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstanceProcessPublicationsRenal AdenocarcinomaRenal Cell AdenocarcinomaRenal Cell CancerRenal Cell CarcinomaResearch ResourcesResourcesScientific PublicationSourceToxic effectToxicitiesTumor Cell LineTumor-Specific Treatment AgentsXenograftXenograft procedureXenotransplantationanaloganti-cancer druganti-cancer therapeuticdevelopmentaldrug candidatein vivo Modelinhibitorkidney adenocarcinomamalignancymodel of animalnaturally occurring compoundnaturally occurring productneoplasm/cancernovelpharmaceuticalpre-clinical evaluationpreclinical evaluationtumor of the central nervous systemtumors in the central nervous systemxeno-transplantxeno-transplantation
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Description preview

Development candidates are moving through the process of preclinical evaluation although resources have been limiting. This includes new animal studies in mouse xenografts as well as mechanistic studies related to toxicity and efficacy of the compounds. Publications are in advanced stages to document these achievements. All of the projects have…

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Development of Natural Product Leads as Anticancer Therapeutics — DIVISION OF BASIC SCIENCES - NCI | UNITED STATES | Dev Procure