grant
Development of nanoscale infrared spectroscopic imaging for measuring cellular ultrastructure
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 25 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20252-photon3-D modeling3D cell culture3D culture3D modelingAlgorithmsAmyloidAmyloid SubstanceAreaArtifactsAtomic Force MicroscopesAtomic Force MicroscopyBiocompatible MaterialsBiologic ModelsBiologicalBiological ModelsBiomaterialsBreathingCancersCatalogingCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCellular TransformationChemicalsCommunitiesComplementComplement ProteinsComputer softwareCoupledCouplingCustomCytoplasmCytosolDataData BanksData BasesDatabanksDatabasesDepositDepositionDevelopmentDevice or Instrument DevelopmentDiseaseDisorderElectric Field MicroscopesElectron MicroscopyElectronicsElementsEndoplasmic ReticulumEngineeringErgastoplasmEvaluationFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyForce MicroscopyFourier TransformGeometryGoalsHealthHumanIR/UV/Raman SpectroscopyImageIntracellular Communication and SignalingInvestigationIonsKnowledgeLabelLaser ElectromagneticLaser RadiationLasersLateral Force MicroscopesLeannessLicensingLifeMachine LearningMagnetic Force MicroscopesMalignant NeoplasmsMalignant TumorMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMechanicsMicro-tubuleMicroscopyMicrotubulesModel SystemModelingModern ManMolecularMorphologic artifactsMorphologyNoiseNuclearOpticsOrganellesPatternPerformancePolymersProcessRaman SpectroscopyRaman Spectrum AnalysisRaman imagingRaman spectrometryReproducibilityResolutionRespiratory AspirationRespiratory InspirationSamplingScanningScanning Force MicroscopyScanning Probe MicroscopesScanning Thermal MicroscopesScanning Tunneling MicroscopesScientific Advances and AccomplishmentsSignal TransductionSignal Transduction SystemsSignalingSoftwareSpectroscopySpectrum AnalysesSpectrum AnalysisSpeedStrains Cell LinesStructureSystemTechniquesTechnologyTestingThickThicknessThinnessTimeTrainingValidationWorkbiologicbiological materialbiological signal transductionbreast cancer progressioncancer progressioncomplementationcultured cell linecustomsdata acquisitiondata acquisitionsdata basedata depositorydata repositorydata set repositorydata sharingdataset repositorydesigndesigningdetectordevelopmentaldevice developmentelectronicelectronic deviceexperimentexperimental researchexperimental studyexperimentsimagingimaging spectroscopyimaging systemimprovedinfrared microscopyinfrared spectroscopyinnovateinnovationinnovativeinnovative technologiesinsightinspirationinstrumentinstrument developmentinstrumentationlithographymachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmacromolecular assemblymalignancymechanicmechanicalmetaplastic cell transformationmulti-photonnano meter scalenano meter sizednanometer scalenanometer sizednanoscaleneoplasm progressionneoplasm/cancerneoplastic progressionnew technologynovelnovel technologiesopticalparallelizationpolymerpolymericpreventpreventingprototypequantumresolutionsscientific accomplishmentsscientific advancessmall moleculespectroscopic imagingtheoriesthree dimensional cell culturethree-dimensional modelingtooltumor progressiontwo-photonvalidations
Description preview
ABSTRACT
Electron and fluorescence microscopy now provide exquisite structural (~ nm) information using specific,
labeled molecular species. However, only a small fraction of cellular species can be illuminated in any
experiment and labeling techniques work primarily for large molecules and assemblies. Small molecules, such
as metabolites, remain…
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