Development of mass spectrometry methods to investigate conformations and complexes of proteins relating to health and disease.
Description preview
Liquid-liquid phase separation (LLPS) of protein molecules is an important process in normal cell physiology, and dysfunctional LLPS is linked with disease states including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). Despite its importance, the molecular mechanisms underlying LLPS remain poorly understood due to a lack of methods…
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